Immunotherapy for metastatic colorectal cancer: Present status and new options

被引：22

作者：

Ellebaek, Eva ^{[1
,2
]}

Andersen, Mads Hald ^{[1
]}

Svane, Inge Marie ^{[1
,2
]}

Straten, Per Thor ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev Hosp, CCIT, Dept Haematol, DK-2730 Herlev, Denmark

[2] Univ Copenhagen, Herlev Hosp, Dept Oncol, DK-2730 Herlev, Denmark

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 47卷 / 03期

关键词：

colorectal neoplasms; immunotherapy; cancer vaccines; adoptive transfer; ACTIVE SPECIFIC IMMUNOTHERAPY; STEM-CELL TRANSPLANTATION; TUMOR-INFILTRATING LYMPHOCYTES; COLONY-STIMULATING FACTOR; ANTIGEN; 5T4; TROVAX; CARCINOEMBRYONIC ANTIGEN; DENDRITIC CELLS; LIVER METASTASES; T-CELLS; IMMUNE-RESPONSES;

D O I：

10.3109/00365521.2012.640831

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although no immunotherapeutic treatment is approved for colorectal cancer (CRC) patients, promising results from clinical trials suggest that several immunotherapeutic strategies may prove efficacious and applicable to this group of patients. This review describes the immunogenicity of CRC and presents the most interesting strategies investigated so far: cancer vaccination including antigen-defined vaccination and dendritic cell vaccination, chemo-immunotherapy, and adoptive cell transfer. Future treatment options as well as the possibility of combining existing therapies will be discussed along with the challenges presented by tumor escape mechanisms.

引用

页码：315 / 324

页数：10

共 50 条

[1] Current status of immunotherapy in metastatic colorectal cancer
Pawel Wrobel
Shahid Ahmed
International Journal of Colorectal Disease, 2019, 34 : 13 - 25
[2] Current status of immunotherapy in metastatic colorectal cancer
Wrobel, Pawel
Ahmed, Shahid
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2019, 34 (01) : 13 - 25
[3] Targeting metastatic colorectal cancer - present and emerging treatment options
Ciombor, Kristen K.
Berlin, Jordan
PHARMACOGENOMICS & PERSONALIZED MEDICINE, 2014, 7 : 137 - 144
[4] New therapeutic options in metastatic colorectal cancer
Czerniawska-Meler, M.
Jagiello-Gruszfeld, A. I.
Zbrzezniak-Smilgiewicz, J.
Szablowska-Siwik, S.
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[5] Metastatic colorectal cancer: Current treatment and future options for improved survival Medical approach - present status
Glimelius, Bengt
Cavalli-Bjorkman, Nina
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2012, 47 (03) : 296 - 314
[6] New treatment options: Polychemotherapy in metastatic colorectal cancer
Rougier, P
EUROCANCER 98, 1998, : 89 - 91
[7] Cervical cancer-immunotherapy in locally advanced and metastatic cervical cancer: status quo and new treatment options
Schubert, M.
Bauerschlag, D. O.
Alkatout, I.
ONKOLOGIE, 2025, 31 (01): : 104 - 109
[8] Colorectal Cancer Immunotherapy: Options and Strategies
Johdi, Nor Adzimah
Sukor, Nur Fazilah
FRONTIERS IN IMMUNOLOGY, 2020, 11
[9] Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives
Zumwalt, Timothy J.
Goel, Ajay
CURRENT COLORECTAL CANCER REPORTS, 2015, 11 (03) : 125 - 140
[10] Treatment options for metastatic colorectal cancer
Senellart, H.
Hiret, S.
Bennouna, J.
ONCOLOGIE, 2010, 12 (10) : 593 - 600

← 1 2 3 4 5 →