50 years of chiral liquid Chromatography. How it started

被引：3
|
作者：
Davankov, Vadim A. [1 ]
机构：
[1] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Dept Stereochem Sorpt Proc, INEOS, Vavilov Str 28, Moscow 119991, Russia
来源：
JOURNAL OF CHROMATOGRAPHY A | 2022年 / 1668卷
关键词：
Chiral LC; Ligand-exchange chromatography; Hypercrosslinked polystyrene; AMINO-ACID ENANTIOMERS; LIGAND CHROMATOGRAPHY; OPTICAL RESOLUTION; SEPARATION;
D O I：
10.1016/j.chroma.2022.462910
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The birth of modern chiral liquid chromatography can be traced back to the years 1968-71 when the first complete resolution of a racemic amino acid was obtained and presented in the literature. Extreme enantioselectivity was achieved due to the introduction of ligand exchange principle, i.e. participation of a copper ion in the solute-sorbent interactions. Simultaneously, first microporous (hypercrosslinked) polymeric matrixes were introduced, thus enhancing the chromatographic efficiency of the process. (c) 2022 Elsevier B.V. All rights reserved.
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页数：3
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