REGENERATE: A Phase 3 International, Placebo-Controlled Study Evaluating Obeticholic Acid Treatment for NASH

被引:0
|
作者
Younossi, Zobair [1 ]
Ratziu, Vlad [2 ]
Dufour, Jean-Francois [3 ]
MacConell, Leigh [4 ]
Shringarpure, Reshma [4 ]
Harrison, Stephen [5 ,6 ]
Sanyal, Arun J. [6 ]
机构
[1] Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA
[2] Sorbonne Univ, Hop Pitie Salpetriere, Paris, France
[3] Univ Bern, Bern, Switzerland
[4] Intercept Pharmaceut, San Diego, CA USA
[5] Pinnacle Clin Res Ctr, San Antonio, TX USA
[6] Virginia Commonwealth Univ, Richmond, VA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
H34
引用
收藏
页码:27S / 27S
页数:1
相关论文
共 50 条
  • [1] POSITIVE RESULTS FROM REGENERATE: A PHASE 3 INTERNATIONAL, RANDOMIZED, PLACEBO-CONTROLLED STUDY EVALUATING OBETICHOLIC ACID TREATMENT FOR NASH
    Younossi, Zobair
    Ratziu, Vlad
    Loomba, Rohit
    Rinella, Mary
    Anstee, Quentin M.
    Zaru, Luna
    MacConell, Leigh
    Shringarpure, Reshma
    Harrison, Stephen
    Sanyal, Arun
    GUT, 2019, 68 : A108 - A108
  • [2] Positive Results From REGENERATE: A Phase 3 International, Randomized, Placebo-Controlled Study Evaluating Obeticholic Acid Treatment for NASH
    Younossi, Zobair
    Ratziu, Vlad
    Loomba, Rohit
    Rinella, Mary
    Anstee, Quentin M.
    Goodman, Zachary
    Bedossa, Pierre
    Geier, Andreas
    Beckebaum, Susanne
    Newsome, Philip
    Sheridan, David
    Trotter, James
    Knapple, Whitfield
    Lawitz, Eric
    Kowdley, Kris
    Montano-Loza, Aldo
    Boursier, Jerome
    Mathurin, Philippe
    Bugianesi, Elisabetta
    Mazzella, Giuseppe
    Olveira, Antonio
    Cortez-Pinto, Helena
    Graupera, Isabel
    Orr, David
    Gluud, Lise Lotte
    Dufour, Jean-Francois
    Shapiro, David
    Campagna, Jason
    Zaru, Luna
    MacConell, Leigh
    Shringarpure, Reshma
    Harrison, Stephen
    Sanyal, Arun
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 : S546 - S546
  • [3] Positive Results from REGENERATE: A Phase 3 International, Randomized, Placebo-Controlled Study Evaluating Obeticholic Acid Treatment for NASH
    Younossi, Zobair
    Ratziu, Vlad
    Loomba, Rohit
    Rinella, Mary
    Anstee, Quentin M.
    Goodman, Zachary
    Bedossa, Pierre
    Geier, Andreas
    Beckebaum, Susanne
    Newsome, Philip
    Sheridan, David
    Trotter, James
    Knapple, Whitfield
    Lawitz, Eric
    Kowdley, Kris
    Montano-Loza, Aldo
    Boursier, Jerome
    Mathurin, Philippe
    Bugianesi, Elisabetta
    Mazzella, Guiseppe
    Olveira, Antonio
    Cortez-Pinto, Helena
    Graupera, Isabel
    Orr, David
    Gluud, Lise Lotte
    Dufour, Jean-Francois
    Shapiro, David
    Campagna, Jason
    Zaru, Luna
    MacConell, Leigh
    Shringarpure, Reshma
    Harrison, Stephen
    Sanyal, Arun
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E5 - E5
  • [4] REGENERATE: A PHASE 3, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED MULTICENTER STUDY OF OBETICHOLIC ACID THERAPY FOR NONALCOHOLIC STEATOHEPATITIS
    Ratziu, V.
    Sanyal, A. J.
    MacConell, L.
    Shringarpure, R.
    Marmon, T.
    Shapiro, D.
    Younossi, Z. M.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S294 - S295
  • [5] Regenerate: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Multicenter Study of Obeticholic Acid Therapy for Nonalcoholic Steatohepatitis
    Younossi, Zobair M.
    Ratziu, Vlad
    Sanyal, Arun J.
    MacConell, Leigh
    Shringarpure, Reshma
    Marmon, Tonya
    Shaprio, David
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 : S1273 - S1273
  • [6] REGENERATE: A Global Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of OCA for NASH
    Ratziu, Vlad
    Sanyal, Arun J.
    MacConell, Leigh
    Herrmann, Sibylle
    Shringarpure, Reshma
    Marmon, Tonya
    Shapiro, David
    Younossi, Zobair M.
    SWISS MEDICAL WEEKLY, 2016, 146 : 17S - 17S
  • [7] A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis
    Kowdley, Kris, V
    Vuppalanchi, Raj
    Levy, Cynthia
    Floreani, Annarosa
    Andreone, Pietro
    LaRusso, Nicholas F.
    Shrestha, Roshan
    Trotter, James
    Goldberg, David
    Rushbrook, Simon
    Hirschfield, Gideon M.
    Schiano, Thomas
    Jin, Yuying
    Pencek, Richard
    MacConell, Leigh
    Shapiro, David
    Bowlus, Christopher L.
    JOURNAL OF HEPATOLOGY, 2020, 73 (01) : 94 - 101
  • [8] A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis
    Nevens, F.
    Andreone, P.
    Mazzella, G.
    Strasser, S. I.
    Bowlus, C.
    Invernizzi, P.
    Drenth, J. P. H.
    Pockros, P. J.
    Regula, J.
    Beuers, U.
    Trauner, M.
    Jones, D. E.
    Floreani, A.
    Hohenester, S.
    Luketic, V.
    Shiffman, M.
    van Erpecum, K. J.
    Vargas, V.
    Vincent, C.
    Hirschfield, G. M.
    Shah, H.
    Hansen, B.
    Lindor, K. D.
    Marschall, H-U
    Kowdley, K. V.
    Hooshmand-Rad, R.
    Marmon, T.
    Sheeron, S.
    Pencek, R.
    MacConell, L.
    Pruzanski, M.
    Shapiro, D.
    NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (07): : 631 - 643
  • [9] Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
    Younossi, Zobair M.
    Ratziu, Vlad
    Loomba, Rohit
    Rinella, Mary
    Anstee, Quentin M.
    Goodman, Zachary
    Bedossa, Pierre
    Geier, Andreas
    Beckebaum, Susanne
    Newsome, Philip N.
    Sheridan, David
    Sheikh, Muhammad Y.
    Trotter, James
    Knapple, Whitfield
    Lawitz, Eric
    Abdelmalek, Manal F.
    Kowdley, Kris V.
    Montano-Loza, Aldo J.
    Boursier, Jerome
    Mathurin, Philippe
    Bugianesi, Elisabetta
    Mazzella, Giuseppe
    Olveira, Antonio
    Cortez-Pinto, Helena
    Graupera, Isabel
    Orr, David
    Gluud, Lise Lotte
    Dufour, Jean-Francois
    Shapiro, David
    Campagna, Jason
    Zaru, Luna
    MacConell, Leigh
    Shringarpure, Reshma
    Harrison, Stephen
    Sanyal, Arun J.
    LANCET, 2019, 394 (10215): : 2184 - 2196
  • [10] Randomized, Placebo-controlled, Phase 3 Study of Itraconazole for the Treatment of Onychomycosis
    Maddin, Stuart
    Quiring, John
    Bulger, Lynne
    JOURNAL OF DRUGS IN DERMATOLOGY, 2013, 12 (07) : 758 - 763