Effect of atropine on the activity of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase in rat brain regions and adrenal glands

被引：1

作者：

Gengin, M. T. ^{[1
]}

Solovev, V. B. ^{[1
]}

机构：

[1] Belinskii State Pedag Univ, Chair Biochem, Penza 440026, Russia

来源：

NEUROCHEMICAL JOURNAL | 2007年 / 1卷 / 03期

关键词：

atropine; brain; carboxypeptidase H; neuropeptides; phenylmethylsulfonylfluoride-inhibited carboxypeptidase;

D O I：

10.1134/S1819712407030075

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of a single atropine administration on the activity of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase (enzymes participating in the final stage of formation of biologically active neuropeptides from their precursors) was studied. A prolonged (for at least 72 h) decrease in the activity of the enzymes was observed. The decrease in the enzymatic activity may be one of the mechanisms of the reduction of neuropeptide level under the action of high doses of atropine.

引用

页码：214 / 218

页数：5

共 11 条

[1] Effect of atropine on the activity of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase in rat brain regions and adrenal glands
M. T. Gengin
V. B. Solovev
Neurochemical Journal, 2007, 1 : 214 - 218
[2] The effect of a single dose of arecholine and atropine administration on activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase in the nervous system of rats
Solov'ev V.B.
Gengin M.T.
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2008, 2 (2) : 183 - 188
[3] Partial characterization of basic phenylmethylsulfonyl fluoride-inhibited carboxypeptidase from cat brain
Vernigora, AN
Nikishin, NN
Gengin, MT
BIOCHEMISTRY-MOSCOW, 1995, 60 (11) : 1423 - 1427
[4] Isolation, Partial Purification, Characterization, and Tissue Distribution of Phenylmethylsulfonyl Fluoride-Inhibited Feline Carboxypeptidase
A. N. Vernigora
M. T. Gengin
Biochemistry (Moscow), 2003, 68 : 80 - 85
[5] Isolation, partial purification, characterization, and tissue distribution of phenylmethylsulfonyl fluoride-inhibited feline carboxypeptidase
Vernigora, AN
Gengin, MT
BIOCHEMISTRY-MOSCOW, 2003, 68 (01) : 80 - 85
[6] Effects of semax on the activity of carboxypeptidase H in brain regions and adrenal glands of rats
Solov'ev, V. B.
Gengin, M. T.
Sollertinskaya, T. N.
Latynova, I. V.
Zhivaeva, L. V.
NEUROCHEMICAL JOURNAL, 2011, 5 (02) : 150 - 152
[7] Effects of semax on the activity of carboxypeptidase H in brain regions and adrenal glands of rats
V. B. Solov’ev
M. T. Gengin
T. N. Sollertinskaya
I. V. Latynova
L. V. Zhivaeva
Neurochemical Journal, 2011, 5 : 150 - 152
[8] Effect of nicotine on the activity of basic carboxypeptidases in rat brain regions and adrenal glands
Solov'ev, V. B.
Gengin, M. T.
NEUROCHEMICAL JOURNAL, 2008, 2 (04) : 259 - 264
[9] Effect of nicotine on the activity of basic carboxypeptidases in rat brain regions and adrenal glands
V. B. Solov’ev
M. T. Gengin
Neurochemical Journal, 2008, 2 : 259 - 264
[10] ACTIVITY OF CARBOXYPEPTIDASE-H IN VARIOUS BRAIN-REGIONS OF RATS WITH VARIOUS RESISTANCE TO EMOTIONAL-STRESS
GENGIN, MT
VERNIGORA, AN
NIKISHIN, NN
KERIMOV, VY
VOPROSY MEDITSINSKOI KHIMII, 1995, 41 (04): : 8 - 9

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