One-pot and step-wise synthesis of thieno[3,2-c] pyridin-4-ones

被引：4

作者：

Sahu, Satya Narayan ^{[1
]}

Singh, Surjeet ^{[1
]}

Shaw, Ranjay ^{[1
]}

Shally ^{[1
]}

Ram, Vishnu Ji ^{[2
]}

Pratap, Ramendra ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India

[2] Univ Lucknow, Dept Chem, Lucknow 226009, Uttar Pradesh, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 88期

关键词：

C BOND FORMATION; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; NMDA-RECEPTOR; UND SCHWEFEL; INHIBITORS; INVITRO; THIENOPYRIDONES; QUINOLONES;

D O I：

10.1039/c6ra17315b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Both one pot and step wise synthesis of methyl 3,5-diaminothieno[3,2-c] pyridin-4-one-2-carboxylates 6 have been delineated by the reaction of 6-aryl-4-methylthio-2H-pyran-2-one-3-carbonitriles 3, methyl mercaptoacetate and hydrazine hydrate. During the stepwise synthesis, functionalized thieno[3,2-c] pyran-4-ones 4 were isolated and treated with hydrazine hydrate to afford the desired products. Analogously, condensation-cyclisation of 5 with hydrazine hydrate delivered identical products, thieno [3,2-c] pyridin-4-ones 6, in excellent yields. The structure of isolated product 6 was ascertained by spectroscopic and single crystal X-ray diffraction analyses.

引用

页码：85515 / 85520

页数：6

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