Design, synthesis and structure-activity relationship of novel coumarin derivatives

被引：44
|
作者：
Guan, Ai-Ying [1 ]
Liu, Chang-Ling [1 ]
Li, Miao [1 ]
Zhang, Hong [1 ]
Li, Zhi-Nian [1 ]
Li, Zheng-Ming [2 ]
机构：
[1] Shenyang Res Inst Chem Ind, State Key Lab Discovery & Dev Novel Pesticide, Shenyang 110021, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
PEST MANAGEMENT SCIENCE | 2011年 / 67卷 / 06期
关键词：
coumarin derivatives; methoxyacrylates; intermediate derivatisation method; fungicidal activities; structure-activity relationship; STROBILURIN DERIVATIVES; FUNGICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; ACARICIDAL ACTIVITY; ALLELOCHEMICALS;
D O I：
10.1002/ps.2103
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
BACKGROUND: The lead coumarin derivative (E)-methyl 3-methoxy-2-[2-(4-methylcoumarin-7-yloxymethyl) phenyl]acrylate was discovered by using an intermediate derivatisation method. To discover new coumarin derivatives with improved activity, a series of substituted coumarins were synthesised and bioassayed. RESULTS: The compounds were identified by H-1 NMR, IR, MS and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activity against cucumber downy mildew at 25 mg L-1. The relationship between structure and fungicidal activity is reported. CONCLUSION: The present work demonstrates that coumarin derivatives containing methoxyacrylate moieties can be used as possible lead compounds for developing novel fungicides. (C) 2011 Society of Chemical Industry
引用
收藏
页码：647 / 655
页数：9
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