Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome

被引：32

作者：

Wang, Kang-Nan ^{[1
]}

Chao, Xi-Juan ^{[1
]}

Liu, Bing ^{[1
]}

Zhou, Dan-Jie ^{[1
]}

He, Liang ^{[1
]}

Zheng, Xiao-Hui ^{[2
]}

Cao, Qian ^{[1
]}

Tan, Cai-Ping ^{[1
]}

Zhang, Chen ^{[3
]}

Mao, Zong-Wan ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[4] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 21期

基金：

美国国家科学基金会;

关键词：

LIVING CELLS; LIVE CELLS; VISCOSITY; RNA; LIFETIME;

D O I：

10.1039/c8cc00256h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two cationic molecular rotors, 1 and 2, capable of real-time cell-cycle imaging by specifically dynamic monitoring of nucleolus and chromosome changes were developed. A further study shows that fluorescence enhancements in the nucleolus and chromosome are attributed to a combination effect of interaction with nucleic acid and high condensation of the nucleolus and chromosome.

引用

页码：2635 / 2638

页数：4

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