Nitric oxide binding and photodelivery based on ruthenium(II) complexes of 4-arylazo-3,5-dimethylpyrazole

被引：20

作者：

Ortiz, Mayreli ^{[1
]}

Torrens, Mabel ^{[1
]}

Mola, Jose L. ^{[2
]}

Ortiz, Pedro J. ^{[3
]}

Fragoso, Alex ^{[4
]}

Diaz, Alicia ^{[1
]}

Cao, Roberto ^{[1
]}

Prados, Pilar ^{[5
]}

de Mendoza, Javier ^{[6
]}

Otero, Antonio ^{[7
]}

Antinolo, Antonio ^{[7
]}

Lara, Agustin ^{[7
]}

机构：

[1] Univ La Habana, Fac Quim, Lab Bioinorgan, Havana 10400, Cuba

[2] Univ La Habana, Fac Quim, Dept Quim Organ, Havana 10400, Cuba

[3] Univ La Habana, Fac Quim, Dept Quim Fis, Havana 10400, Cuba

[4] Univ Rovira & Virgili, Dept Engn Quim, Tarragona 43007, Spain

[5] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[6] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[7] Univ Castilla La Mancha, Dept Quim Organ Inorgan & Bioquim, E-13071 Ciudad Real, Spain

来源：

DALTON TRANSACTIONS | 2008年 / 27期

关键词：

D O I：

10.1039/b718645b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two fluorescent ligands, 3,5-dimethyl- 4-(6'-sulfonylammonium-1'-azonaphthyl)pyrazole (dmpzn, 1) and 3,5-dimethyl-4-(4'-N, N'-dimethylaminoazophenyl)pyrazole (dmpza, 2) were obtained by condensation of ketoenolic derivatives with hydrazine. 1 and 2 formed the novel dinuclear complexes [(H2O)3ClRu(mu-L)(2)RuCl(H2O)(3)] (3 or 4) and [(H2O)(NO)Cl2Ru(mu-L)(2)RuCl2(NO)(H2O)] (6 or 7) (where L = 1 or 2, respectively) which were characterized by IR, NMR and elemental analysis. The nitrosyl complexes were prepared by bubbling purified nitric oxide through methanol solutions of the corresponding ruthenium(II) chloroderivative or by reaction of the appropriate ligands with Ru(NO)Cl-3. Complexes 3 and 4 were found to bind NO, resulting in an increase in fluorescence. Ligand 1 also formed the mononuclear nitrosyl complex [Ru(NO)(bpy)(2)(dmpzn)]Cl-2 (8) which released NO in water at physiological pH and in the solid state as revealed by fluorescence and IR measurements, respectively.

引用

页码：3559 / 3566

页数：8

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