Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

被引：22
|
作者：
Han, SY [1 ]
Cho, SH
Kim, SY
Seo, JT
Moon, SJ
Jhon, GJ
机构：
[1] Ewha Womans Univ, Dept Chem, Res Inst Basic Sci, Seoul 120750, South Korea
[2] Ewha Womans Univ, Life Sci Res Inst, Seoul 120750, South Korea
[3] Yonsei Univ, Coll Dent, Dept Oral Biol, Seoul 120749, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(98)00690-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several monoacetyldiglycerides were synthesized from glycerol in search fbr new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：59 / 64
页数：6
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