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- [1] Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of ActionJOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (23) : 10619 - 10634Han, XingchunZhou, ChengangJiang, MinWang, YongguangWang, JianhuaCheng, ZhanlingWang, MinLiu, YongqiangLiang, ChungenWang, JianpingWang, ZhanguoWeikert, RobertLv, WenzheXie, JianxunYu, XinZhou, XueLuangsay, SouphaloneShen, Hong C.Mayweg, Alexander V.Javanbakht, HassanYang, Song
- [2] Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (15) : 6668 - 6678Clark, Michael P.Ledeboer, Mark W.Davies, IoanaByrn, Randal A.Jones, Steven M.Perola, EmanueleTsai, AliceJacobs, MarcNti-Addae, KwameBandarage, Upul K.Boyd, Michael J.Bethiel, Randy S.Court, John J.Deng, HongboDuffy, John P.Dorsch, Warren A.Farmer, Luc J.Gao, HuaiGu, WenxinJackson, KatrinaJacobs, Dylan H.Kennedy, Joseph M.Ledford, BrianLiang, JianglinMaltais, FrancoisMurcko, MarkWang, TianshengWannamaker, M. WoodsBennett, Hamilton B.Leeman, Joshua R.McNeil, ColleenTaylor, William P.Memmott, ChristineJiang, MinRijnbrand, ReneBral, ChristopherGermann, UrsulaNezami, AzinZhang, YuegangSalituro, Francesco G.Bennani, Youssef L.Charifson, Paul S.
- [3] Discovery of VX-787: A novel, first-in-class, orally bioavailable azaindole inhibitor of influenza PB2ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248Clark, Michael P.
- [4] Discovery of a first-in-class, potent, selective and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083)ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252Zhou, Han-Jie
- [5] Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (24) : 9480 - 9497Zhou, Han-JieWang, JinhaiYao, BingWong, SteveDjakovic, StevanKumar, BrajeshRice, JulieValle, EduardoSoriano, FerdieMenon, Mary-KamalaMadriaga, Antonettvon Soly, Szerenke KissKumar, AbhinavParlati, FrancescoYakes, F. MichaelShawver, LauraLe Moigne, RonanAnderson, Daniel J.Rolfe, MarkWustrow, David
- [6] Phase 1 trial evaluating TTI-101, a first-in-class, orally bioavailable, small molecule, inhibitor of STAT3, in patients with advanced solid tumorsJOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)Tsimberidou, Apostolia MariaVining, David J.Arora, Sukeshi Patelde Achaval, SofiaLarson, JeffreyCartwright, CarrieAvritscher, RonyAlibhai, ImranKaseb, Ahmed Omar
- [7] Discovery and validation of biomarkers to support clinical development of NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitorEUROPEAN JOURNAL OF CANCER, 2022, 174 : S35 - S35Workman, P.Clarke, P. A.Poele, R. TePowers, M.Box, G.De Billy, E.Brandon, A. De HavenHallsworth, A.Hayes, A.McCann, H.Sharp, S.Valenti, M.Raynaud, F. I.Eccles, S. A.Cheeseman, M.Jones, K.
- [8] BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolismCANCER RESEARCH, 2024, 84 (09)Beltran, PedroDhirendra, SimanshuXu, RuiChen, MingCzyzyk, DanielDonovan, SofiaFeng, SiyuFeng, CindyFu, LijuanLightstone, FeliceLin, KenMaciag, AnnaNissley, DwightRiegler, ErinSinkevicius, KerstinStephen, AndrewStice, JamesTurner, DavidWang, BinWang, KeshiYang, YueZhang, CathyMcCormick, FrankWallace, Eli
- [9] Target Expression, Preclinical Activity and Mechanism of Action of EM801: A Novel First-in-Class Bcma T-Cell Bispecific Antibody for the Treatment of Multiple MyelomaBLOOD, 2015, 126 (23)Seckinger, AnjaDelgado, Jose AntonioMoreno, LauraNeuber, BrigitteGrab, AnnaLipp, SusanneMerino, JuanaVu, Minh DiemStrein, KlausProsper, FelipeHundemer, MichaelMiguel, Jesus SanHose, DirkPaiva, Bruno
- [10] Target expression, preclinical activity and mechanism of action of EM801: a novel first-in-class IgG-based BCMA T-cell bispecific antibody for the treatment of multiple myelomaONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 207 - 208Seckinger, A.Delgado, J. A.Moreno, L.Neuber, B.Grab, A. L.Lipp, S.Merino, J.Vu, M. D.Strein, K.Prosper, F.Hundemer, M.San Miguel, J.Hose, D.Paiva, B.