The Recql5 Helicase Is a Novel Downstream Target of Jak2V617F and Maintains Genome Stability in Response to Replication Stress

被引：9
|
作者：
Chen, Edwin [1 ]
Ahn, Jong-Sook [2 ]
Breyfogle, Lawrence J. [1 ]
Green, Anthony R. [2 ]
Ebert, Benjamin L. [1 ]
Mullally, Ann [1 ,3 ,4 ]
机构：
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Univ Cambridge, Cambridge, England
[3] Broad Inst, Cambridge, MA USA
[4] Harvard Univ, Sch Med, Boston, MA USA
来源：
BLOOD | 2014年 / 124卷 / 21期
关键词：
D O I：
10.1182/blood.V124.21.4773.4773
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Identification of AIM2 as a downstream target of JAK2V617F
    Liew E.L.
    Araki M.
    Hironaka Y.
    Mori S.
    Tan T.Z.
    Morishita S.
    Edahiro Y.
    Ohsaka A.
    Komatsu N.
    Experimental Hematology & Oncology, 5 (1)
  • [2] RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability
    Chen, Edwin
    Ahn, Jong Sook
    Sykes, David B.
    Breyfogle, Lawrence J.
    Godfrey, Anna L.
    Nangalia, Jyoti
    Ko, Amy
    DeAngelo, Daniel J.
    Green, Anthony R.
    Mullally, Ann
    CELL REPORTS, 2015, 13 (11): : 2345 - 2352
  • [3] The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
    Holmstrom, M. O.
    Hjortso, M. D.
    Ahmad, S. M.
    Met, O.
    Martinenaite, E.
    Riley, C.
    Straten, P.
    Svane, I. M.
    Hasselbalch, H. C.
    Andersen, M. H.
    LEUKEMIA, 2017, 31 (02) : 495 - 498
  • [4] The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
    M O Holmström
    M D Hjortsø
    S M Ahmad
    Ö Met
    E Martinenaite
    C Riley
    P Straten
    I M Svane
    H C Hasselbalch
    M H Andersen
    Leukemia, 2017, 31 : 495 - 498
  • [5] THE JAK2V617F MUTATION IS A POTENTIAL TARGET FOR CANCER IMMUNE THERAPY
    Holmstrom, M. O.
    Hjortso, M. D.
    Ahmad, S. M.
    Met, O.
    Martinenaite, E.
    Riley, C.
    Straten, P. T.
    Svane, I. M.
    Hasselbalch, H. C.
    Andersen, M. H.
    HAEMATOLOGICA, 2016, 101 : 189 - 189
  • [6] A novel regulating role of JAK2 FERM domain in hyperactivation of JAK2V617F
    Zhao, Lequn
    Huang, Lily
    CANCER RESEARCH, 2009, 69
  • [7] Enhanced Molecular Response in Myeloproliferative Neoplasms with Complete JAK2V617F Inhibition
    Celik, Hamza
    Challen, Grant A.
    CANCER DISCOVERY, 2024, 14 (05) : 701 - 703
  • [8] The cell cycle regulator CDC25A is a target for JAK2V617F oncogene
    Gautier, Emilie-Fleur
    Picard, Muriel
    Laurent, Camille
    Marty, Caroline
    Villeval, Jean-Luc
    Demur, Cecile
    Delhommeau, Francois
    Hexner, Elizabeth
    Giraudier, Stephane
    Bonnevialle, Nicolas
    Ducommun, Bernard
    Recher, Christian
    Laurent, Guy
    Manenti, Stephane
    Mansat-De Mas, Veronique
    BLOOD, 2012, 119 (05) : 1190 - 1199
  • [9] The Cell Cycle Regulator CDC25A Is a Target for JAK2V617F Oncogene
    Gautier, Emilie-Fleur
    Recher, Christian
    Laurent, Camille
    Marty, Caroline
    Villeval, Jean-Luc
    Demur, Cecile
    Delhommeau, Francois
    Hexner, Elizabeth
    Giraudier, Stephane
    Bonnevialle, Nicolas
    Ducommun, Bernard
    Laurent, Guy
    Manenti, Stephane
    Mansat-De Mas, Veronique
    BLOOD, 2011, 118 (21) : 606 - 606
  • [10] The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera
    Falchi, Mario
    Varricchio, Lilian
    Martelli, Fabrizio
    Marra, Manuela
    Picconi, Orietta
    Tafuri, Agostino
    Girelli, Gabriella
    Uversky, Vladimir N.
    Migliaccio, Anna Rita
    EXPERIMENTAL HEMATOLOGY, 2017, 50 : 53 - 76
12345