STRUCTURES OF CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE: HOLOENZYME AND TERNARY INHIBITOR COMPLEXES

被引：0
|
作者：
Whitlow, Marc [1 ]
Howard, Andrew J. [1 ]
Stewart, David [1 ]
Hardman, Karl D. [1 ]
Kuyper, Lee F. [2 ]
Baccanari, David P. [2 ]
Fling, Mary [2 ]
Chan, Joseph H. [2 ]
Tansik, Robert L. [2 ]
机构：
[1] Genex Corp, Gaithersburg, MD 20877 USA
[2] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA
来源：
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 1996年 / 52卷
关键词：
D O I：
10.1107/S0108767396091027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
PS04.12.37
引用
下载
收藏
页码：C208 / C209
页数：2
相关论文
共 50 条
  • [1] X-ray crystallographic studies of Candida albicans dihydrofolate reductase - High resolution structures of the holoenzyme and an inhibited ternary complex
    Whitlow, M
    Howard, AJ
    Stewart, D
    Hardman, KD
    Kuyper, LF
    Baccanari, DP
    Fling, ME
    Tansik, RL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) : 30289 - 30298
  • [2] X-ray crystal structures of Candida albicans dihydrofolate reductase:: High resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor
    Whitlow, M
    Howard, AJ
    Stewart, D
    Hardman, KD
    Chan, JH
    Baccanari, DP
    Tansik, RL
    Hong, JS
    Kuyper, LF
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (18) : 2928 - 2932
  • [3] CHARACTERIZATION OF CANDIDA-ALBICANS DIHYDROFOLATE-REDUCTASE
    BACCANARI, DP
    TANSIK, RL
    JOYNER, SS
    FLING, ME
    SMITH, PL
    FREISHEIM, JH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (02) : 1100 - 1107
  • [4] COMPARISON OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE INHIBITOR-COFACTOR TERNARY COMPLEXES.
    Galitsky, Nikolai
    Cody, Vivian
    Luft, Joseph R.
    Pangborn, Walter
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C234 - C234
  • [5] DIHYDROFOLATE-REDUCTASE (DHFR) FROM CANDIDA-ALBICANS AND SACCHAROMYCES CEREVISIAE
    BACCANARI, DP
    FLING, M
    FREISHEIM, J
    JOYNER, S
    TANSIK, R
    FEDERATION PROCEEDINGS, 1987, 46 (06) : 1973 - 1973
  • [6] Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans
    DeJarnette, Christian
    Luna-Tapia, Arturo
    Estredge, Leanna R.
    Palmer, Glen E.
    MSPHERE, 2020, 5 (03):
  • [7] SEQUENCE OF A DIHYDROFOLATE REDUCTASE-ENCODING GENE FROM CANDIDA-ALBICANS
    DALY, S
    MASTROMEI, G
    YACOUB, A
    LORENZETTI, R
    GENE, 1994, 147 (01) : 115 - 118
  • [8] ACTIVITY OF SULFA DRUGS AND DIHYDROFOLATE-REDUCTASE INHIBITORS AGAINST CANDIDA-ALBICANS
    BUSH, K
    FREUDENBERGER, JS
    SLUSARCHYK, DS
    SYKES, RB
    MEYERS, E
    EXPERIENTIA, 1982, 38 (04): : 436 - 437
  • [9] A DIHYDROFOLATE-REDUCTASE GENE FROM CANDIDA-ALBICANS - MOLECULAR-CLONING
    FRANCESCHI, M
    DENARO, M
    IRDANI, T
    LORENZETTI, R
    MASTROMEI, G
    SKARMOUTSOU, E
    POLSINELLI, M
    FEMS MICROBIOLOGY LETTERS, 1991, 80 (2-3) : 179 - 182
  • [10] Studies on the inhibitor-binding site of porcine aldehyde reductase: Crystal structure of the holoenzyme-inhibitor ternary complex
    ElKabbani, O
    Carper, DA
    McGowan, MH
    Devedjiev, Y
    ReesMilton, KJ
    Flynn, TG
    PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1997, 29 (02): : 186 - 192
12345