Heparin-induced extracorporeal low-density lipoprotein precipitation

被引：8

作者：

Mellwig, KP ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Univ Hosp, Herz & Diabeteszentrum NRW,Dept Cardiol, N Rhine Westphalia Heart & Diabet Ct, D-32545 Bad Oeynhausen, Germany

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2003年 / 7卷 / 03期

关键词：

adhesion molecules; coronary vasodilation capacity; heparin-induced extracorporeal LDL precipitation; LDL apheresis; PET;

D O I：

10.1046/j.1526-0968.2003.00051.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) is a selective and careful apheresis procedure. Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50-60%. In addition, adhesion molecules (ICAM-1, VCAM-1, p-selectin) which play a key role in the development and progression of atherosclerosis, are also markedly reduced. A PET scan performed 20 h after LDL apheresis shows the improvement of coronary vasodilation capacity. This is supposed to be mainly due to the marked reduction of LDL cholesterol and fibrinogen with consecutive improvement of endothelial dysfunction and rheology.

引用

页码：365 / 369

页数：5

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