The Significance of Non-T-Cell Pathways in Graft Rejection: Implications for Transplant Tolerance

被引：22

作者：

Li, Xian Chang ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Transplant Inst, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Surg,Transplant Inst, Boston, MA 02215 USA

来源：

TRANSPLANTATION | 2010年 / 90卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Innate immunity; NK cells; Dendritic cells; Tolerance; Transplantation; NATURAL-KILLER-CELLS; DENDRITIC CELLS; NK CELLS; B-CELLS; ALLOGRAFT VASCULOPATHY; REGULATORY CELLS; MEMORY; INTERLEUKIN-15; REQUIREMENT; ACTIVATION;

D O I：

10.1097/TP.0b013e3181efcfe9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Both innate and adaptive immune cells are actively involved in the initiation and destruction of allotransplants, and there is a true need now to look beyond T cells in the allograft response, examining various non-T-cell types in transplant models and how such cell types interact with T cells in determining the fate of an allograft. Studies in this area may lead to further improvement in transplant outcomes.

引用

页码：1043 / 1047

页数：5

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