Cp2ZrCl2-mediated three-component coupling reactions of CO2, ethylene (or alkynes), and electrophiles leading to carboxylic acid derivatives

被引：22
|
作者：
Yamashita, K [1 ]
Chatani, N [1 ]
机构：
[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
来源：
SYNLETT | 2005年 / 06期
关键词：
carbon dioxide; carboxylic acids; Grignard reactions; metallacycles; nucleophilic additions; alkynes;
D O I：
10.1055/s-2005-864807
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Zirconacycles 1 and 2 can be simply generated from CP2ZrCl2, EtMgBr, and an atmospheric pressure Of CO2. The treatment of CP2ZrCl2 with EtMgBr followed by exposure to CO2 generates zirconacycle 1, which can react with various electrophiles to give a variety of carboxylic acid derivatives. Unsaturated zircona-cycles 2 can also generated from CP2ZrCl2, EtMgBr, alkynes, and CO2. Complexes 2 react with electrophiles to give alpha,beta-unsaturated acids stereoselectively.
引用
收藏
页码：919 / 922
页数：4
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