Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging

被引：204
|
作者：
Eberlin, Livia S.
Ferreira, Christina R.
Dill, Allison L.
Ifa, Demian R.
Cooks, R. Graham [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2011年 / 1811卷 / 11期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Ambient mass spectrometry; Imaging; Lipidomics; Disease diagnosis; Desorption electrospray ionization; Lipid characterization; FATTY-ACID COMPOSITIONS; CHOLESTEROL SULFATE; INFILTRATING LESIONS; PARTIAL SEPARATION; PHOSPHOLIPIDS; CANCER; BRAIN; DESI; PROFILES; CELLS;
D O I：
10.1016/j.bbalip.2011.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：946 / 960
页数：15
相关论文
共 50 条
  • [1] Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry
    Bennett, Rachel V.
    Gamage, Chaminda M.
    Fernandez, Facundo M.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2013, (77):
  • [2] Tissue imprint imaging by desorption electrospray ionization mass spectrometry
    Ifa, Demian R.
    Srimany, Amitava
    Eberlin, Livia S.
    Naik, Hemanta R.
    Bhat, Vasudeva
    Cooks, R. Graham
    Pradeep, T.
    ANALYTICAL METHODS, 2011, 3 (08) : 1910 - 1912
  • [3] Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections
    Garza, Kyana Y.
    Feider, Clara L.
    Klein, Dustin R.
    Rosenberg, Jake A.
    Brodbelt, Jennifer S.
    Eberlin, Livia S.
    ANALYTICAL CHEMISTRY, 2018, 90 (13) : 7785 - 7789
  • [4] Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
    Laskin, Julia
    Heath, Brandi S.
    Roach, Patrick J.
    Cazares, Lisa
    Semmes, O. John
    ANALYTICAL CHEMISTRY, 2012, 84 (01) : 141 - 148
  • [5] Desorption Electrospray Ionization then MALDI Mass Spectrometry Imaging of Lipid and Protein Distributions in Single Tissue Sections
    Eberlin, Livia S.
    Liu, Xiaohui
    Ferreira, Christina R.
    Santagata, Sandro
    Agar, Nathalie Y. R.
    Cooks, R. Graham
    ANALYTICAL CHEMISTRY, 2011, 83 (22) : 8366 - 8371
  • [6] Nondestructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry
    Eberlin, Livia S.
    Ferreira, Christina R.
    Dill, Allison L.
    Ifa, Demian R.
    Cheng, Liang
    Cooks, R. Graham
    CHEMBIOCHEM, 2011, 12 (14) : 2129 - 2132
  • [7] Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging
    Comi, Troy J.
    Ryu, Seung Woo
    Perry, Richard H.
    ANALYTICAL CHEMISTRY, 2016, 88 (02) : 1169 - 1175
  • [8] Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry
    Li, Bin
    Bjarnholt, Nanna
    Hansen, Steen H.
    Janfelt, Christian
    JOURNAL OF MASS SPECTROMETRY, 2011, 46 (12): : 1241 - 1246
  • [9] Imaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry
    Carson, Richard H.
    Lewis, Charlotte R.
    Erickson, Mercede N.
    Zagieboylo, Anna P.
    Naylor, Bradley C.
    Li, Kelvin W.
    Farnsworth, Paul B.
    Price, John C.
    JOURNAL OF LIPID RESEARCH, 2017, 58 (09) : 1884 - 1892
  • [10] Direct Plant Tissue Analysis and Imprint Imaging by Desorption Electrospray Ionization Mass Spectrometry
    Mueller, Thomas
    Oradu, Sheran
    Ifa, Demian R.
    Cooks, R. Graham
    Kraeutler, Bernhard
    ANALYTICAL CHEMISTRY, 2011, 83 (14) : 5754 - 5761
12345