Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

被引：14

作者：

Choi, Sungim ^{[1
]}

Kim, Min-Chul ^{[1
,2
]}

Kwon, Ji-Soo ^{[1
]}

Kim, Ji-Yeun ^{[1
]}

Lee, Keun Hwa ^{[3
]}

Kim, Sung-Han ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Infect Dis, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea

[2] Chung Ang Univ Hosp, Dept Internal Med, Div Infect Dis, Seoul, South Korea

[3] Jeju Natl Univ, Coll Med, Dept Microbiol & Immunol, Jeju, South Korea

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2018年 / 99卷 / 06期

关键词：

INFLUENZA; BUNYAVIRUS; DISEASE;

D O I：

10.4269/ajtmh.17-0766

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We describe the case of a patient with severe fever with thrombocytopenia syndrome (SFTS) complicated by SFTS-associated encephalopathy who was successfully treated with 4-day plasma exchange followed by two-time convalescent plasma therapy. During plasma exchange, the plasma cytokines interferon-a and inducible protein-10 gradually decreased without change of plasma viral load. However, plasma viral load gradually decreased after convalescent plasma therapy. This case provides important insights for understanding the mechanisms of experimental therapy in severely affected SFTS patients.

引用

页码：1466 / 1468

页数：3