S3 Guideline: Sepsis 2018

被引：1

作者：

Brunkhorst, F. M. ^{[1
]}

Weigand, M. A. ^{[2
]}

Pletz, M. ^{[3
]}

Gastmeier, P. ^{[4
]}

Lemmen, S. W. ^{[5
]}

Meier-Hellmann, A. ^{[6
]}

Ragaller, M. ^{[7
]}

Weyland, A. ^{[8
]}

Marx, G. ^{[9
]}

Bucher, M. ^{[10
]}

Gerlach, H. ^{[11
]}

Salzberger, B. ^{[12
]}

Grabein, B. ^{[13
]}

Welte, T. ^{[14
]}

Werdan, K. ^{[15
]}

Kluge, S. ^{[16
]}

Bone, H. G. ^{[17
]}

Putensen, C. ^{[18
]}

Rossaint, R. ^{[19
]}

Quintel, M. ^{[20
]}

Spies, C. ^{[21
]}

Weiss, B. ^{[21
]}

John, S. ^{[22
]}

Oppert, M. ^{[23
]}

Joerres, A. ^{[24
]}

Brenner, T. ^{[2
]}

Elke, G. ^{[25
]}

Gruendling, M. ^{[26
]}

Mayer, K. ^{[27
]}

Weimann, A. ^{[28
]}

Felbinger, T. W. ^{[29
]}

Axer, I. I. ^{[30
]}

Heller, H. ^{[31
]}

Gagelmann, N. ^{[32
]}

机构：

[1] Univ Klinikum Jena, Zentrum Klin Studien Integriertes Forschungs & Be, Klin Anasthesiol & Intensivmed, Klinikum 1, D-07747 Jena, Germany

[2] Univ Klinikum Heidelberg, Klin Anasthesiol, Heidelberg, Germany

[3] Univ Klinikum Jena, Inst Infektionsmed & Krankenhaus Hyg, Jena, Germany

[4] Charite Univ Med Berlin, Inst Hyg & Umweltmed, Berlin, Germany

[5] Univ Klinikum Aachen, Zentralbereich Krankenhaushyg & Infektiol, Aachen, Germany

[6] Helios Klinikum Erfurt GmbH, Klin Anasthesie Intensivmed & Schmerztherapie, Erfurt, Germany

[7] Univ Klinikum Dresden, Klin & Poliklin Anasthesiol & Intensivtherapie, Dresden, Germany

[8] Klinikum Oldenburg gGmbH, Klin Anasthesiol, Intensivmed, Notfallmed,Schmerztherapie, Oldenburg, Germany

[9] Univ Klinikum Aachen, Klin Operat Intensivmed & Intermediate Care, Aachen, Germany

[10] Univ Klinikum Halle, Klin Anasthesiol & Operat Intensivmed, Halle, Germany

[11] Vivantes Klinikum Neukolln, Klin Anasthesie Operat Intensivmed & Schmerzthera, Berlin, Germany

[12] Univ Klinikum Regensburg, Abt Krankenhaushyg & Infektiol, Regensburg, Germany

[13] Klinikum Univ Munchen, Stabsstelle Klin Mikrobiol & Krankenhaushyg, Munich, Germany

[14] Hannover Med Sch, Klin Pneumol, Hannover, Germany

[15] Klinikum MLU Halle Wittenberg, Univ Klin & Poliklin Innere Med 3, Halle, Germany

[16] Univ Klinikum Hamburg Eppendorf, Klin Intensivmed, Hamburg, Germany

[17] Knappschaftskrankenhaus Recklinghausen, Zentrum Anasthesiol Intensivmed & Schmerztherapie, Recklinghausen, Germany

[18] Univ Klinikum Bonn, Klin Anasthesiol & Operat Intensivmed, Bonn, Germany

[19] Univ Klinikum Aachen, Klin Anasthesiol, Aachen, Germany

[20] Univ Med Gottingen, Klin Anasthesiol, Gottingen, Germany

[21] Charite Univ Med Berlin, Klin Anasthesiol Schwerpunkt Operat Intensivmed, Berlin, Germany

[22] Klinikum Nurnberg, Klin Innere Med 8, Schwerpunkt Kardiol, Nurnberg, Germany

[23] Klinikum Ernst von Bergmann Potsdam, Klin Notfall & Internist Intensmed, Potsdam, Germany

[24] Klinikum Univ Witten Herdecke, Krankenhaus Merhe, Med Klin 1, Klin Nephrol Transplantationsmed & Internist Inte, Witten, Germany

[25] Univ Klinikum Kiel, Klin Anasthesiol & Operat Intensivmed, Kiel, Germany

[26] Univ Klinikum Greifswald, Klin Anasthesiol Anasthesie Intens Notfall & Schm, Greifswald, Germany

[27] Klinikum Justus Liebig Univ Giessen, Med Klin & Poliklin 2, Giessen, Germany

[28] Klinikum St Georg Leipzig gGmbH, Klin Allgemein Viszeral & Onkol Chirurg, Leipzig, Germany

[29] Stadt Klinikum Munchen, Klin Anasthesiol Operat Intensivmed & Schmerzther, Munich, Germany

[30] Univ Klinikum Jena, Klin Neurol, Jena, Germany

[31] Univ Klinikum Jena, Jena, Germany

[32] Univ Klinikum Hamburg Eppendorf, Hamburg, Germany

来源：

ANASTHESIOLOGIE & INTENSIVMEDIZIN | 2020年 / 61卷

关键词：

Sepsis; Diagnosis; Therapy; Management; Aftercare;

D O I：

10.19224/ai2020.178

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Sepsis is an acute life-threatening organ dysfunction resulting from an inadequate host response to an infection. The diagnosis of sepsis-associated organ dysfunction should be based on a change of >= 2 points using the Sequential Organ Failure Assessment (SOFA) score. An intravenous crystalloid solution should be administered within the first 3 hours to achieve a haemodynamic stabilisation of the patient. A 0.9% NaCl solution should NOT be used. A schematic minimum infusion amount and a general target value for the mean arterial blood pressure are not recommended. Intravenous anti-infectives should be administered as soon as possible if possible within 1 hour after confirmed diagnosis. The application of an empirical broad-spectrum antibiotic or multiple antibiotics is recommended in order to account for all significant bacteria. Measurements of the procalcitonin value should be done to shorten the duration of antimicrobial therapy.

引用

页码：178 / 188

页数：11

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