Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

被引：43

作者：

Liao, Guochao ^{[1
]}

Zhou, Zhifang ^{[1
]}

Guo, Zhongwu ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 47期

关键词：

MENINGOCOCCAL DISEASE; NEISSERIA-MENINGITIDIS; STEREOSELECTIVE-SYNTHESIS; POLYSACCHARIDE VACCINE; CARBOHYDRATE VACCINES; OLIGOSIALIC ACIDS; SIALIC-ACID; DONORS; IMMUNOGENICITY; THIOSIALOSIDE;

D O I：

10.1039/c5cc01794g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. alpha-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis.

引用

页码：9647 / 9650

页数：4

共 6 条

[1] Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis
Liao, Guochao
Zhou, Zhifang
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Mondal, Mohabul A.
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ACS CENTRAL SCIENCE, 2016, 2 (04) : 210 - 218
[2] Synthesis and immunological studies of group A Streptococcus cell-wall oligosaccharide-streptococcal C5a peptidase conjugates as bivalent vaccines
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ORGANIC CHEMISTRY FRONTIERS, 2019, 6 (20): : 3589 - 3596
[3] Synthesis, anti-tuberculosis activity and 3D-QSAR study of amino acid conjugates of 4-(adamantan-1-yl) group containing quinolines
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[4] Click chemistry-assisted synthesis of novel C-2 triazole-linked betulinic acid conjugates with azidothymidine as potential anti-HIV agents
Spivak, Anna Yu
Nedopekina, Darya A.
Galimshina, Zulfiya R.
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Gubaidullin, Rinat R.
Odinokov, Victor N.
ARKIVOC, 2018, : 1 - 19
[5] ANTIBODIES TO POLY[(2-]8)-ALPHA-N-ACETYLNEURAMINIC ACID] AND POLY[(2-]9)-ALPHA-N-ACETYLNEURAMINIC ACID] ARE ELICITED BY IMMUNIZATION OF MICE WITH ESCHERICHIA-COLI K92 CONJUGATES - POTENTIAL VACCINES FOR GROUP-B AND GROUP-C MENINGOCOCCI AND ESCHERICHIA-COLI K1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) : 7175 - 7179
[6] SYNTHESIS OF 2-S-DIOXO ISOSTERES OF PURINE AND PYRIMIDINE NUCLEOSIDES .5. C-13-DNMR STUDY OF SYN-ANTI EQUILIBRIUM IN A GLUCOSIDE OF A N-SUBSTITUTED BARBITURIC-ACID ISOSTERE
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