Efficacy of topical adapalene monotherapy for symptomatic relief in a long-standing vulvar syringoma: A case report and literature review with treatment update

We present a middle-aged Japanese female case of vulvar and facial syringomas, a very rare clinical phenotype of the disease, with severe intractable itching. The skin manifestation and symptom were unresponsive to topical corticosteroids and persisted for more than a decade, but her vulvar itching dramatically improved with topical adapalene monotherapy. We discuss the treatment dilemma of vulvar syringomas and the pharmaceutical mechanism of action of adapalene for satisfactory symptomatic relief in our case.