NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells

被引：11

作者：

Margolis, David J. ^{[1
]}

Hampton, Michelle ^{[1
]}

Hoffstad, Ole ^{[1
]}

Mala, D. Scot ^{[2
]}

Mirza, Ziad ^{[3
]}

Woltereck, Diana ^{[3
]}

Shannon, Steven ^{[2
]}

Troiano, Michael A. ^{[2
]}

Mitra, Nandita ^{[4
]}

Yang, Ming ^{[5
]}

Bhopale, Veena M. ^{[5
]}

Thom, Stephen R. ^{[5
]}

机构：

[1] Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Penn Presbyterian Med Ctr, Podiatr Surg & Med, Philadelphia, PA USA

[3] Greater Baltimore Med Ctr, Dept Med, Baltimore, MD USA

[4] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

[5] Univ Maryland, Sch Med, Dept Emergency Med, Baltimore, MD 21201 USA

来源：

WOUND REPAIR AND REGENERATION | 2017年 / 25卷 / 04期

关键词：

NITRIC-OXIDE; COMMON VARIATION; AMPUTATION; USERS;

D O I：

10.1111/wrr.12564

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that NOS1AP variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it NOS1AP might be associated with a functional impairment.

引用

页码：733 / 736

页数：4

共 24 条

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Hoffstad, O. J.
Yang, M.
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PLOS ONE, 2013, 8 (12):
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DIABETES, 2012, 61 : A31 - A31
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DIABETOLOGIA, 2011, 54 : S471 - S472
[5] Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study
Eijgelsheim, Mark
Newton-Cheh, Christopher
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HUMAN MOLECULAR GENETICS, 2009, 18 (21) : 4213 - 4218
[6] Human CD34+stem cells promote healing of diabetic foot ulcers in rats
Elsharawy, Mohamed A.
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Greish, Sahar
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2012, 14 (03) : 288 - 293
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DIABETOLOGIA, 2018, 61 : S7 - S7
[8] Genetic variation in the NOS1AP gene is associated with the incidence of diabetes mellitus in users of calcium channel blockers
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L. E. Visser
C. Newton-Cheh
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A. Hofman
A. G. Uitterlinden
B. H. Ch. Stricker
Diabetologia, 2008, 51 : 2138 - 2140
[9] Genetic variation in the NOS1AP gene is associated with the incidence of diabetes mellitus in users of calcium channel blockers
Becker, M. L.
Visser, L. E.
Newton-Cheh, C.
Witteman, J. C. M.
Hofman, A.
Uitterlinden, A. G.
Stricker, B. H. Ch.
DIABETOLOGIA, 2008, 51 (11) : 2138 - 2140
[10] INCREASED POPULATION OF CD40+FIBROBLASTS IS ASSOCIATED WITH IMPAIRED WOUND HEALING AND CHRONIC INFLAMMATION IN DIABETIC FOOT ULCERS
Littig, J. P.
Moellmer, R.
Agrawal, D. K.
Rai, V
JOURNAL OF INVESTIGATIVE MEDICINE, 2023, 71 (01) : NP42 - NP43

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