Knockdown of ANGPTL2 promotes cardiac left ventricular dysfunction in mice via up-regulation of NOX4

被引：0
|
作者：
Labbe, Pauline [1 ]
Martel, Cecile [1 ]
Shi, Yan-Fen [2 ]
Gillis, Marc-Antoine [2 ]
Duquette, Natacha [2 ]
Mamarbachi, Maya [2 ]
Tardif, Jean-Claude [2 ]
Thorin-Trescases, Nathalie [2 ]
Thorin, Eric [1 ]
机构：
[1] Univ Montreal, Fac Med, Dept Pharmacol, Montreal, PQ, Canada
[2] Montreal Heart Inst, Montreal, PQ, Canada
来源：
FASEB JOURNAL | 2020年 / 34卷
基金：
加拿大健康研究院;
关键词：
D O I：
10.1096/fasebj.2020.34.s1.05201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice
    Labbe, Pauline
    Martel, Cecile
    Shi, Yan-Fen
    Montezano, Augusto
    He, Ying
    Gillis, Marc-Antoine
    Higgins, Marie-Eve
    Villeneuve, Louis
    Touyz, Rhian
    Tardif, Jean-Claude
    Thorin-Trescases, Nathalie
    Thorin, Eric
    FRONTIERS IN PHYSIOLOGY, 2024, 15
  • [2] ANGPTL2 Counteracts the Age-Associated Hypertrophic Effects of Cardiac NOX4 Activity in Mice
    Labbe, Pauline
    Martel, Cecile
    Shi, Yanfen
    Gillis, Marc-Antoine
    Higgins, Marie-Eve
    Mamarbachi, Maya
    Tardif, Jean-Claude
    Thorin-Trescases, Nathalie
    Thorin, Eric
    CIRCULATION RESEARCH, 2022, 131 (12) : E178 - E178
  • [3] NADPH Oxidase Nox4 Up-regulation Contributes to the Worsening of Pressure Overload induced Cardiac Dysfunction in Angiopoeitin-like 2 Knockdown Mice
    Martel, Cecile
    Raignault, Adeline
    Yu, Carol
    Gillis, Marc-Antoine
    Mamarbachi, Maya
    Bousette, Nicolas
    Duquette, Natacha
    Thorin-Trescases, Nathalie
    Rosiers, Christine Des
    Thorin, Eric
    CIRCULATION, 2015, 132
  • [4] Oleic acid-induced ANGPTL4 facilitates metastasis of human colorectal cancer via up-regulation of NOX4 expression
    Shen, Chih-Jie
    Liao, Yu-Han
    Tsai, Jhih-Peng
    Hung, Liang-Yi
    Chang, Wen-Chang
    Chen, Ben-Kuen
    CANCER RESEARCH, 2019, 79 (13)
  • [5] Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction
    Tian, Zhe
    Miyata, Keishi
    Morinaga, Jun
    Horiguchi, Haruki
    Kadomatsu, Tsuyoshi
    Endo, Motoyoshi
    Zhao, Jiabin
    Zhu, Shunshun
    Sugizaki, Taichi
    Sato, Michio
    Terada, Kazutoyo
    Okumura, Takahiro
    Murohara, Toyoaki
    Oike, Yuichi
    CIRCULATION JOURNAL, 2018, 82 (02) : 437 - +
  • [6] Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes
    Ago, Tetsuro
    Kuroda, Junya
    Pain, Jayashree
    Fu, Cexiong
    Li, Hong
    Sadoshima, Junichi
    CIRCULATION RESEARCH, 2010, 106 (07) : 1253 - U183
  • [7] The Erk1/2-pathway is involved in PKC-induced Nox4 up-regulation
    Schlufter, F.
    Xia, N.
    Foerstermann, U.
    Li, H.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2012, 385 : 82 - 83
  • [8] Up-regulation of NOX1/NADPH oxidase following drug-induced myocardial injury promotes cardiac dysfunction and fibrosis
    Iwata, Kazumi
    Matsuno, Kuniharu
    Murata, Ayumi
    Zhu, Kai
    Fukui, Hitomi
    Ikuta, Keiko
    Katsuyama, Masato
    Ibi, Masakazu
    Matsumoto, Misaki
    Ohigashi, Makoto
    Wen, Xiaopeng
    Zhang, Jia
    Cui, Wenhao
    Yabe-Nishimura, Chihiro
    FREE RADICAL BIOLOGY AND MEDICINE, 2018, 120 : 277 - 288
  • [9] Selective up-regulation of preproenkephalin mRNA in left ventricular myocardium in rats with cardiac hypertrophy
    Weil, J
    Eschenhagen, T
    Mittmann, C
    Orthey, E
    Wenzel, U
    Scholz, H
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R616 - R616
  • [10] NOX4 NADPH Oxidase Mediates Diastolic Dysfunction in Stress Cardiomyopathy via Regulation of Inflammation and Fibrosis
    Vendrov, Aleksandr E.
    Xiao, Han
    Lozhkin, Andrey
    Madamanchi, Nageswara R.
    Zhang, Youyi
    Runge, Marschall
    CIRCULATION, 2020, 142
12345