On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate

被引：29
|
作者：
Saunthwal, Rakesh K. [1 ]
Patel, Monika [1 ]
Tiwari, Rakesh K. [2 ]
Parang, Keykavous [2 ]
Verma, Akhilesh K. [1 ]
机构：
[1] Univ Delhi, Dept Chem, Synthet Organ Chem Lab, Delhi 110007, India
[2] Chapman Univ, Coll Pharm, Orange, CA 92866 USA
来源：
GREEN CHEMISTRY | 2015年 / 17卷 / 03期
关键词：
SUPERCRITICAL CARBON-DIOXIDE; TANDEM SYNTHESIS; FLUOROUS MEDIA; ACID-DERIVATIVES; MICHAEL ADDITION; EFFICIENT; 3,4-DIHYDROQUINAZOLINE-2(1H)-THIONES; CYCLIZATION; ALKENES; FACILE;
D O I：
10.1039/c4gc02154a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A green and catalyst-free atom-ecomonic straightforward tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of 2-aminophenylacrylates with isothiocyanates using water as an environmentally friendly solvent via amidation and concomitant chemoselective Michael-addition is described.
引用
收藏
页码：1434 / 1441
页数：8
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