Interactions between Radiation and One-Carbon Metabolism

被引：5
|
作者：
Korimerla, Navyateja [1 ,2 ]
Wahl, Daniel R. [1 ,2 ]
机构：
[1] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期
关键词：
one-carbon metabolism; radiation therapy; cancer therapy; folate cycle; methionine cycle; INDUCED GENOMIC INSTABILITY; BODY GAMMA-IRRADIATION; IONIZING-RADIATION; FOLATE-DEFICIENCY; HISTONE METHYLATION; DNA METHYLATION; FOLIC-ACID; RECOMBINANT METHIONINASE; OXIDATIVE STRESS; GLYCINE BETAINE;
D O I：
10.3390/ijms23031919
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.
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页数：14
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