Synthesis of 1 alpha,3 beta-dihydroxy-2 beta-(3-hydroxypropoxy)-5,7-choladiene derivative and its application to the synthesis of 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3

被引：1

作者：

Tachibana, Y

机构：

[1] Pharmaceutical Research Center of Nisshin Flour Milling Co. Ltd., Tsurugaoka, Ooimachi, Irurna-gun

来源：

NIPPON KAGAKU KAISHI | 1996年 / 01期

关键词：

D O I：

10.1246/nikkashi.1996.91

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from 22-benzoyloxy-3 beta-(t-butyldimethylsilyloxy)-5 alpha,8 alpha-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-1,6-choladiene (5), the PTAD (4-phenyl-3H-1,2,4-triazole-3,5-(4H)-dione) adduct of 1 alpha,3 beta-dihydroxy-2 beta-(3-hydroxypropoxy)-23,24-dinor-5,7-choladiene derivative (3) was synthesized. The steroidal synthon (3) was converted to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (2). Oxidation of 3 afforded the corresponding C-20 carbaldehyde (4).

引用

页码：91 / 96

页数：6

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