Comparison of different prognostic scores for patients with cirrhosis hospitalized with SARS-CoV-2 infection

被引：17

作者：

Mendizabal, Manuel ^{[1
,2
]}

Ridruejo, Ezequiel ^{[2
,3
]}

Pinero, Federico ^{[1
,2
]}

Anders, Margarita ^{[2
,4
]}

Padilla, Martin ^{[5
]}

Toro, Luis G. ^{[6
]}

Torre, Aldo ^{[7
]}

Montes, Pedro ^{[8
]}

Urzua, Alvaro ^{[9
]}

Gonzalez Ballerga, Esteban ^{[10
]}

Dolores Silveyra, Maria ^{[11
]}

Michelato, Douglas ^{[12
]}

Diaz, Javier ^{[13
]}

Peralta, Mirta ^{[2
,14
]}

Pages, Josefina ^{[1
,2
]}

Ruiz Garcia, Sandro ^{[15
]}

Gutierrez Lozano, Isabel ^{[16
]}

Macias, Yuridia ^{[17
]}

Cocozzella, Daniel ^{[2
,18
]}

Chavez-Tapia, Norberto ^{[19
]}

Tagle, Martin ^{[20
]}

Dominguez, Alejandra ^{[21
]}

Varon, Adriana ^{[2
,22
]}

Pozo, Emilia Vera ^{[23
]}

Higuera-de la Tijera, Fatima ^{[24
]}

Bustios, Carla ^{[25
]}

Conte, Damian ^{[26
]}

Escajadillo, Nataly ^{[27
]}

Gomez, Andres J. ^{[28
]}

Tenorio, Laura ^{[13
]}

Castillo Barradas, Mauricio ^{[29
]}

Isabel Schinoni, Maria ^{[2
,30
]}

Bessone, Fernando ^{[31
]}

Contreras, Fernando ^{[32
]}

Nazal, Leyla ^{[33
]}

Sanchez, Abel ^{[34
]}

Garcia, Matias ^{[3
]}

Brutti, Julia ^{[11
]}

Cecilia Cabrera, Maria ^{[8
]}

Miranda-Zazueta, Godolfino ^{[7
]}

Rojas, German ^{[10
]}

Cattaneo, Maximo ^{[10
]}

Castro-Narro, Graciela ^{[19
]}

Rubinstein, Fernando ^{[35
]}

Silva, Marcelo O. ^{[1
,2
]}

机构：

[1] Univ Austral, Hosp Univ Austral, Hepatol & Liver Transplant Unit, Pilar, Argentina

[2] Latin Amer Liver Res Educ & Awareness Network LAL, Buenos Aires, DF, Argentina

[3] Ctr Educ Med & Invest Clin, Liver Sect, Buenos Aires, DF, Argentina

[4] Hosp Aleman, Hepatol & Liver Transplant Unit, Buenos Aires, DF, Argentina

[5] Hosp Nacl Guillermo Almenara Irigoyen, Gastroenterol Unit, Lima, Peru

[6] Hospitales San Vicente Fdn Medellin & Rionegro, Hepatol & Liver Transplant Unit, Medellin, Colombia

[7] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Gastroenterol, Ciudad De Mexico, Mexico

[8] Hosp Nacl Daniel A Carrion, Gastroenterol Unit, Callao, Peru

[9] Hosp Clin Univ Chile, Internal Med Dept, Gastroenterol Sect, Santiago, Chile

[10] Univ Buenos Aires, Hosp Clin Jose de San Martin, Dept Gastroenterol, Buenos Aires, DF, Argentina

[11] Sanatorio Anchorena, Dept Internal Med, Buenos Aires, DF, Argentina

[12] Hosp Especializado Enfermedades Infecciosas Inst, Salvador De Bahia, Brazil

[13] Hosp Nacl Edgardo Rebagliati Martins, Lima, Peru

[14] Hosp Infecciosas Francisco J Muniz, Intens Care Unit, Buenos Aires, DF, Argentina

[15] Hosp Victor Lazarte Echegaray, Gastroenterol Unit, Trujillo, Peru

[16] Ctr Med ABC, Dept Internal Med, Ciudad De Mexico, Mexico

[17] IMSS Hosp Gen Reg 1 Dr Carlos Mc Gregor Sanchez, Dept Med, Ciudad De Mexico, Mexico

[18] Hosp Italiano La Plata, Dept Gastroenterol, La Plata, Argentina

[19] Med Sur Clin & Fdn, Ciudad De Mexico, Mexico

[20] Clin Anglo Amer, Gastroenterol Unit, Lima, Peru

[21] Hosp Padre Hurtado, Dept Gastroenterol, Santiago, Chile

[22] Fdn Cardioinfantil, Liver Unit, Bogota, Colombia

[23] Hosp Reg Dr Teodoro Maldonado Carbo IESS, Guayaquil, Ecuador

[24] Hosp Gen Mexico Dr Eduardo Liceaga, Dept Gastroenterol & Hepatol, Ciudad De Mexico, Mexico

[25] Clin Delgado, Gastroenterol Unit, Lima, Peru

[26] Hosp Privado Cordoba, Unidad Higado, Cordoba, Argentina

[27] Hosp Nacl Almanzor Aguinaga Asenjo, Gastroenterol Unit, Chiclayo, Peru

[28] Hosp Univ Fdn Santa Fe Bogota, Endoscopy & Transplant Serv, Bogota, Colombia

[29] Hosp Especialidades Ctr Med Nacl La Raza IMSS, Gastroenterol Unit, Ciudad De Mexico, Mexico

[30] Hosp Alianza, Dept Gastroenterol, Salvador, BA, Brazil

[31] Hosp Prov Centenario, Dept Gastroenterol, Rosario, Argentina

[32] CEDIMAT, Dept Gastroenterol, Santo Domingo, Dominican Rep

[33] Clin Las Condes, Dept Gastroenterol, Santiago, Chile

[34] Hosp Roosevelt, Dept Gastroenterol, Ciudad De Guatemala, Guatemala

[35] Inst Efectividad Clin & Sanitaria, Buenos Aires, DF, Argentina

来源：

ANNALS OF HEPATOLOGY | 2021年 / 25卷

关键词：

COVID-19; Death; Pandemic; Acute-on-chronic liver failure; Coronavirus; Cirrhosis; DYSFUNCTION;

D O I：

10.1016/j.aohep.2021.100350

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction and Objectives: Viral infections have been described to increase the risk of decompensation in patients with cirrhosis. We aimed to determine the effect of SARS-CoV-2 infection on outcome of hospitalized patients with cirrhosis and to compare the performance of different prognostic models for predicting mortality. Patients: We performed a prospective cohort study including 2211 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through October 1, 2020 in 38 Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters of patients with and without cirrhosis. All patients were followed until discharge or death. We evaluated the prognostic performance of different scoring systems to predict mortality in patients with cirrhosis using ROC curves. Results: Overall, 4.6% (CI 3.7-5.6) subjects had cirrhosis (n = 96). Baseline Child-Turcotte-Pugh (CTP) class was assessed: CTP-A (23%), CTP-B (45%) and CTP-C (32%); median MELD-Na score was 19 (IQR 14-25). Mortality was 47% in patients with cirrhosis and 16% in patients without cirrhosis (P < .0001). Cirrhosis was independently associated with death [OR 3.1 (CI 1.9-4.8); P .0001], adjusted by age, gender, and body mass index 30. The areas under the ROC curves for performance evaluation in predicting 28-days mortality for Chronic Liver Failure Consortium (CLIF-C), North American Consortium for the Study of End-Stage Liver Disease (NACSELD), CTP score and MELD-Na were 0.85, 0.75, 0.69, 0.67; respectively (P < .0001). Conclusions: SARS-CoV-2 infection is associated with elevated mortality in patients with cirrhosis. CLIF-C had better performance in predicting mortality than NACSELD, CTP and MELD-Na in patients with cirrhosis and SARS-CoV-2 infection. (C) 2021 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.

引用

页数：8

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