T Cells Activation and Interferon-γ/Nitric Oxide Production during Behcet Disease: A Study in Algerian Patients

被引：12

作者：

Djaballah-Ider, Fatmazohra ^{[1
]}

Chaib, Samia ^{[2
]}

Belguendouz, Houda ^{[1
]}

Talbi, Djameleddine ^{[3
]}

Touil-Boukoffa, Chafia ^{[1
]}

机构：

[1] USTHB, FSB, LBCM, Team Cytokines & Synth, Algiers 16111, Algeria

[2] Ain Naadja Hosp, Dept Immunol, Algiers, Algeria

[3] Ain Naadja Hosp, Dept Internal Med, Algiers, Algeria

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2012年 / 20卷 / 03期

关键词：

Behcet's disease; CD; interferon gamma; nitric oxide; cytokine; NITRIC-OXIDE; UVEITIS; GAMMA;

D O I：

10.3109/09273948.2012.671882

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The aim of the current study is to situate CDs expression (CD3+, CD4+, CD8+) and their relationship with IFN gamma and NO production in Algerian patients with Behcet disease (n=34). Our results revealed an elevated expression of T cells markers tested in patients in active stage of the disease in relation to IFN gamma and NO increase levels. Most interestingly, we noted that CD4+/CD8+ expression correlated with IFN gamma and NO production in active stage. In contrast, we observed a decrease of these mediators in inactive stage. Collectively, our results indicate a dependent relation between these parameters and inflammatory response associated with the evolutionary stage of the disease.

引用

页码：215 / 217

页数：3

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