Menstruation-Related Disorders-Dysmenorrhea and Heavy Bleeding-as Significant Epiphenomena in Women With Rheumatic Diseases

被引：5

作者：

Orlandi, Martina ^{[1
,2
,3
]}

Vannuccini, Silvia ^{[4
]}

El Aoufy, Khadija ^{[1
,2
,3
]}

Melis, Maria Ramona ^{[1
,2
,3
]}

Lepri, Gemma ^{[1
,2
,3
]}

Sambataro, Gianluca ^{[5
]}

Bellando-Randone, Silvia ^{[1
,2
,3
]}

Guiducci, Serena ^{[1
,2
,3
]}

Cerinic, Marco Matucci ^{[1
,2
,3
,6
]}

Petraglia, Felice ^{[4
]}

机构：

[1] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[2] AOUC, Div Rheumatol, Florence, Italy

[3] Scleroderma Unit, Florence, Italy

[4] AOU Careggi Florence, Dept Matern & Infancy, Obstet & Gynecol, Florence, Italy

[5] Artroreuma SRL, Rheumatol Outpatient Clin Associated Natl Hlth Sy, Catania, Italy

[6] IRCCS San Raffaele Hosp, Unit Immunol Rheumatol Allergy & Rare Dis UnIRAR, Milan, Italy

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

heavy menstrual bleeding; menstruation disorders; dysmenorrhea; dyspareunia; rheumatic and musculoskeletal disease; gynecological diseases; rheumatic disease; PRIMARY SJOGRENS-SYNDROME; ADENOMYOSIS; PHYSIOLOGY; HEALTH;

D O I：

10.3389/fphar.2022.807880

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: In women with rheumatic diseases (RDs) menstruation-related disorders have never been investigated. The aim of this study was to evaluate gynecological symptoms/disorders in fertile age women with RDs.Materials and methods: All patients (n = 200) filled up a self-administered questionnaire on their gynecological history, menstrual cycle pattern, menstrual-related symptoms, and quality of life (QoL). The RD group was then compared to a control group of 305 age-matched fertile age women.Results: Among patients with RDs, 58% had arthritis, 40% connective tissue diseases (CTDs), and 1.5% systemic vasculitis. No differences were observed between CTDs and arthritis, except for a family history of HMB which was more common among women with CTDs (p < .01). When compared to controls, women with RDs reported more frequent heavy menstrual bleeding (HMB) during adolescence (51.7 and 25.4%, respectively; p = .0001) and adult life (37.7 and 25.9%, respectively; p = .0065). Also, dysmenorrhea in adolescence was significantly more common among cases (55.6 and 45.4%, respectively; p = .0338). Gynecological pain (dysmenorrhea, non-menstrual pelvic pain, dyspareunia, dysuria, and dyschezia) in patients with RDs was more frequent than in controls (p = .0001, .0001, .0001, .0001, .0002, respectively). Considering women who reported moderate and severe symptoms in RDs, dysmenorrhea and dyspareunia remain significantly more frequent in women with RDs than in controls (p = .0001; p = .0022; respectively). QoL scores were significantly reduced in women with RDs, either in physical (p = .0001) and mental domains (p = .0014) of short-form 12.Conclusion: Women affected by RDs frequently presented menstruation-related disorders; thus, female patients with RDs should be questioned about gynecological symptoms and referred to the gynecologist for an accurate evaluation.

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页数：8