Malabsorption of rifampin and isoniazid in HIV-infected patients with and without tuberculosis

被引：84
|
作者：
Gurumurthy, P
Ramachandran, G
Kumar, AKH
Rajasekaran, S
Padmapriyadarsini, C
Swaminathan, S
Venkatesan, P
Sekar, L
Kumar, S
Krishnarajasekhar, OR
Paramesh, P
机构：
[1] Indian Council Med Res, Div TB Res Ctr, Madras 600031, Tamil Nadu, India
[2] Govt Hosp Thorac Med, Madras, Tamil Nadu, India
来源：
CLINICAL INFECTIOUS DISEASES | 2004年 / 38卷 / 02期
关键词：
D O I：
10.1086/380795
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The absorption of rifampin, isoniazid, and D-xylose in patients with human immunodeficiency virus (HIV) infection and diarrhea, in patients with HIV infection and tuberculosis ( TB), in patients with pulmonary TB alone, and in healthy subjects was studied. Percentage of dose of the drugs, their metabolites, and D-xylose excreted in urine were calculated. A significant reduction in the absorption of drugs and D-xylose in both the HIV infection/diarrhea and HIV infection/ TB groups was observed (P<.05), and the correlation between them was significant. Our results indicate that patients with HIV infection and diarrhea and those with HIV infection and TB have malabsorption of rifampin and isoniazid.
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收藏
页码：280 / 283
页数：4
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