Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer

被引:96
|
作者
Zhou, J
Allred, DC
Avis, I
Martínez, A
Vos, MD
Smith, L
Treston, AM
Mulshine, JL
机构
[1] NCI, Intervent Sect, Dept Cell & Canc Biol, Med Branch,Div Clin Sci,NIH, Bethesda, MD 20892 USA
[2] Baylor Coll Med, Breast Ctr, Houston, TX 77030 USA
关键词
breast carcinogenesis; early detection marker; immunohistochemistry; intermediate endpoint marker;
D O I
10.1023/A:1010631915831
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP-A2/B1) is highly expressed during critical stages of lung development and carcinogenesis. To determine if the expression of hnRNP-A2/B1 is an informative biomarker in breast carcinogenesis, we analyzed hnRNP-A2/B1 overexpression by immunohistochemistry in archived specimens. Expression was detected in 48/85 (56.5%) primary invasive breast cancers and 7/72 (9.7%) specimens of normal breast tissue. Northern analysis of breast cancer cells also demonstrated higher level of hnRNP-A2/B1 expression compared to normal or transformed breast cells. Expression of hnRNP-A2/B1 in breast cancer cells was decreased by exposure to retinoids coordinately with decreased cell growth. These results warrant further evaluation of hnRNP-A2/B1 as a marker of breast carcinogenesis.
引用
收藏
页码:217 / 224
页数:8
相关论文
共 50 条
  • [21] Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways
    Liu, Yu
    Li, Huan
    Liu, Fan
    Gao, Li-Bin
    Han, Rong
    Chen, Chen
    Ding, Xue
    Li, Shuang
    Lu, Kun
    Yang, Ling
    Tian, Hui-Min
    Chen, Bin-Bin
    Li, Xiao
    Xu, Dong-Hui
    Deng, Xiao-Ling
    Shi, Song-Lin
    EBIOMEDICINE, 2020, 51
  • [22] Expression of heterogeneous nuclear ribonucleoprotein A2/B1 in bronchial epithelium of chronic smokers
    Zhou, J
    Mulshine, JL
    Ro, JY
    Avis, I
    Yu, R
    Lee, JJ
    Morice, R
    Lippman, SM
    Lee, JS
    CLINICAL CANCER RESEARCH, 1998, 4 (07) : 1631 - 1640
  • [23] Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma
    Jing, Guang-Jun
    Xu, Dong-Hui
    Shi, Song-Lin
    Li, Qi-Fu
    Wang, San-Ying
    Wu, Fu-Yun
    Kong, Hai-Yan
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 (01) : 108 - 115
  • [24] Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells
    Yan-Sanders, Y
    Hammons, GJ
    Lyn-Cook, BD
    CANCER LETTERS, 2002, 183 (02) : 215 - 220
  • [25] Expression of hnRNP A2/B1 proteins in human cancer cell lines
    Satoh, H
    Kamma, H
    Ishikawa, H
    Horiguchi, H
    Fujiwara, M
    Yamashita, YT
    Ohtsuka, M
    Sekizawa, K
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2000, 16 (04) : 763 - 767
  • [26] Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer
    Zech, Veronika F. E.
    Dlaska, Margit
    Tzankov, Alexandar
    Hilbe, Wolfgang
    CANCER DETECTION AND PREVENTION, 2006, 30 (05): : 395 - 402
  • [27] Overexpression of hnRNPA2/B1 in Bronchoscopic Specimens: A Potential Early Detection Marker in Lung Cancer
    Katsimpoula, S.
    Patrinou-Georgoula, M.
    Makrilia, N.
    Dimakou, K.
    Guialis, A.
    Orfanidou, D.
    Syrigos, K. N.
    ANTICANCER RESEARCH, 2009, 29 (04) : 1373 - 1382
  • [28] The splicing factor hnRNP A2/B1 is a biomarker and a driving oncogene in glioblastoma and metastatic breast cancer
    Golan-Gerstl, R.
    Shilo, A.
    Loinger, I.
    Reich, R.
    Davidson, B.
    Jacobs, J.
    Cesarkas, K.
    Rechavi, G.
    Rigo, F.
    Bennett, F.
    Karni, R.
    TUMOR BIOLOGY, 2012, 33 : 55 - 55
  • [29] Heterogeneous nuclear ribonucleoprotein A2/B1, a key regulator of myocardial fibrosis
    Jeong, Ji-Hoon
    John, Kayode Abidemi
    Hong, Juyeong
    Lee, Ji Hoon
    CLINICAL AND TRANSLATIONAL DISCOVERY, 2024, 4 (03):
  • [30] Role of ITGB2 in patients with luminal B1 breast cancer
    Liu, Chun-Yu
    Chen, Ji-Lin
    Tsai, Yi-Fang
    Chao, Ta-Chung
    Wang, Wan-Lun
    Lien, Pei-Ju
    Hsu, Chih-Yi
    Lai, Jiun-I
    Huang, Chi-Cheng
    Chiu, Jen-Hwey
    Tseng, Ling-Ming
    CANCER RESEARCH, 2024, 84 (06)