Preparation and Performance of Controlled-Release Tablets of Sasanquasaponin-Casein

被引：2

作者：

Liu Xiao-zhen ^{[1
]}

Yang Jun-hua ^{[1
]}

Song Ling-ling ^{[2
]}

Song Yue-xing ^{[1
]}

Lai Zhong-fan ^{[3
]}

Zhai Li ^{[1
]}

机构：

[1] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China

[2] Gannan Normal Univ, Univ Hosp, Ganzhou 341000, Peoples R China

[3] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto 8608555, Japan

来源：

SPECTROSCOPY AND SPECTRAL ANALYSIS | 2012年 / 32卷 / 06期

关键词：

Sasanquasaponin; Casein; Controlled-release tablets; IR spectra; UV-Vis absorption spectra;

D O I：

10.3964/j.issn.1000-0593(2012)06-1650-04

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The controlled-release tablets of sasanquasaponin (SQS)-casein were prepared by using SQS, casein and guar gum as the main drug and accessory materials respectively. The method of determination of SQS in the controlled-release tablets of SQS-casein, and the effects of release media on the release rate and IR spectra of the controlled-release tablets of SQS-casein were studied, respectively. The release rate curve of the controlled-release tablets of SQS-casein was fitted as zero order, one order and Higuchi equation. The recovery was 98.59% when the content of SQS in the controlled-release tablets of SQS-casein in phosphate buffer solution (pH 6.8) as release media was determined with chromogenic reaction of vanillin-sulfuric acid. The release rates are 23.80%, 51.26% and 94.77% at release times 3, 6 and 12 h, respectively in phosphate buffer solution (pH 6.8) as release media. The controlled-release tablets of SQS-casein release SQS by slowness and constant in 12 h. The chemical bonds are formed among SQS, casein and guar gum.

引用

页码：1650 / 1653

页数：4

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