Synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component reaction in poly(ethylene glycol)

被引：65
|
作者：
Zareai, Zeinab [3 ]
Khoobi, Mehdi [2 ]
Ramazani, Ali [3 ]
Foroumadi, Alireza [2 ]
Souldozi, Ali [4 ]
Slepokura, Katarzyna [5 ]
Lis, Tadeusz [5 ]
Shafiee, Abbas [1 ,2 ]
机构：
[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14176, Iran
[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14176, Iran
[3] Univ Zanjan, Dept Chem, Zanjan, Iran
[4] Islamic Azad Univ, Urmia Branch, Dept Chem, Orumiyeh, Iran
[5] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland
来源：
TETRAHEDRON | 2012年 / 68卷 / 33期
基金：
美国国家科学基金会;
关键词：
Multicomponent reaction; Furo[3,2-c]coumarin; 4-Hydroxycoumarin; Oxidation; X-ray single crystal structure analysis; Poly(ethylene glycol); MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; FACILE SYNTHESIS; CYCLOADDITION; DERIVATIVES; SYSTEM;
D O I：
10.1016/j.tet.2012.05.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2 equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I-2 and K2S2O8 in the presence of Na2CO3 was used as an oxidative reagent. The structure of the furo[3,2-c]coumarins was established by X-ray single crystal structure analysis. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6721 / 6726
页数：6
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