Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin

被引：0
|
作者：
Xu Fei [1 ]
Zhang Linqun [2 ,3 ]
He Liwei [1 ]
Gu Wei [1 ]
Fang Fang [1 ]
Wu Qinan [1 ]
Zhao Bo [4 ]
机构：
[1] Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China
[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China
[3] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210097, Peoples R China
[4] Nanjing Normal Univ, Coll Chem & Environm Sci, Nanjing 210097, Peoples R China
来源：
ACTA CHIMICA SINICA | 2011年 / 69卷 / 19期
关键词：
alisol B 23-acetate; alisol A 24-acetate; fluorescence spectra; circular dichroism spectra; molecular modeling; ANTICANCER DRUG; BINDING; DNA;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The anti-tumor effect of Traditional Chinese Medicine Alisma may be related to the change of protein components in serum. The molecular interaction mechanism of Alisols with Human Serum Albumin (HSA) was investigated by fluorescence and circular dichroism spectra in combination with molecular modeling under the simulated physiological conditions in the paper. Molecular modeling results are in agreement with the experimental results revealed that the binding of Alisol B 23-acetate and HSA was much more stronger than that with Alisol A 24-acetate, indicating that the difference is related to the structure of the side chain. The conclusion should be of great assistant for studying formulations of Alisma and the anti-tumor mechanism.
引用
收藏
页码：2228 / 2234
页数：7
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