The library of cinchona alkaloids-1,2,3-triazole derivatives: Structure and facile access by "click chemistry"

被引：11

作者：

Kacprzak, K ^{[1
]}

Migas, M ^{[1
]}

Plutecka, A ^{[1
]}

Rychlewska, U ^{[1
]}

Gawronski, J ^{[1
]}

机构：

[1] Adam Mickiewicz Univ Poznan, Dept Chem, PL-60780 Poznan, Poland

来源：

HETEROCYCLES | 2005年 / 65卷 / 08期

关键词：

Cinchona alkaloid; 1,2,3-triazole; click chemistry; 1,3-dipolar cycloaddition; Huisgen cycloaddition;

D O I：

10.3987/COM-05-10378

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New Cinchona alkaloids-1,2,3-triazole derivatives library was prepared readily and efficiently using Huisgen 1,3-dipolar cycloaddition of 9-azido substituted Cinchona alkaloids and various terminal and disubstituted alkynes (click chemistry). Spectroscopic, X-Ray, and molecular modelling data show that these derivatives maintain the conformation of the parent alkaloids.

引用

页码：1931 / 1938

页数：8

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