Engineered T cells and their therapeutic applications in autoimmune diseases

被引：13
|
作者：
Bao, Lei [1 ]
Bo, Xiao-Chen [1 ]
Cao, Huai-Wen [1 ]
Qian, Chen [1 ]
Wang, Zeng [1 ]
Li, Bin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China
来源：
ZOOLOGICAL RESEARCH | 2022年 / 43卷 / 02期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Chimeric antigen receptor T cells; Cell immunotherapy; Autoimmune diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-CELL; RHEUMATOID-ARTHRITIS; PEMPHIGUS-VULGARIS; CD19; CAR; CLINICAL DEVELOPMENT; MICROSCOPIC COLITIS; GENE-TRANSFER; IN-VITRO; ANTIGEN;
D O I：
10.24272/j.issn.2095-8137.2021.363
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.
引用
收藏
页码：150 / 165
页数：16
相关论文
共 50 条
  • [1] Engineered T cells and their therapeutic applications in autoimmune diseases
    Lei Bao
    Xiao-Chen Bo
    Huai-Wen Cao
    Chen Qian
    Zeng Wang
    Bin Li
    Zoological Research, 2022, 43 (02) : 150 - 165
  • [2] Therapeutic potential of antigen receptor-engineered regulatory T cells for immunotherapy of autoimmune diseases
    Pohar, Jelka
    O'Connor, Richard
    Manfroi, Benoit
    El-Behi, Mohamed
    Jouneau, Luc
    Boudinot, Pierre
    Bunse, Mario
    Uckert, Wolfgang
    Luka, Marine
    Menager, Mickael
    Liblau, Roland
    Anderton, Stephen M.
    Fillatreau, Simon
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2023, 53 : 67 - 68
  • [3] Engineered immune cells as therapeutics for autoimmune diseases
    Zouali, Moncef
    TRENDS IN BIOTECHNOLOGY, 2024, 42 (07) : 842 - 858
  • [4] Natural killer T cells as targets for therapeutic intervention in autoimmune diseases
    Wilson, MT
    Van Kaer, L
    CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (03) : 201 - 220
  • [5] CAR T-cells: New therapeutic opportunities in autoimmune diseases?
    Chou, Mei-Chia
    Lee, Wei-Kai
    Yeh, Wen-Bin
    Yong, Su-Boon
    Li, Chia-Jung
    Chang, Renin
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2023, 26 (08) : 1427 - 1428
  • [6] Follicular helper T cells in autoimmune diseases A good therapeutic target?
    Papp, Gabor
    Szabo, Krisztina
    Szekanecz, Zoltan
    Zeher, Margit
    RHEUMATOLOGY, 2014, 53 (07) : 1159 - 1160
  • [7] B cells as a therapeutic target in autoimmune diseases
    Park, YW
    Pryshchep, S
    Seyler, TM
    Goronzy, JJ
    Weyand, CM
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2005, 9 (03) : 431 - 445
  • [8] Potential therapeutic applications of exosomes in different autoimmune diseases
    Xu, Hui
    Jia, Shaochang
    Xu, Hanmei
    CLINICAL IMMUNOLOGY, 2019, 205 : 116 - 124
  • [9] Immunological GABAergic interactions and therapeutic applications in autoimmune diseases
    Prud'homme, Gerald J.
    Glinka, Yelena
    Wang, Qinghua
    AUTOIMMUNITY REVIEWS, 2015, 14 (11) : 1048 - 1056
  • [10] The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases
    Chao Yang
    Mingjun Wu
    Min You
    Yu Chen
    Maowen Luo
    Qiang Chen
    Stem Cell Research & Therapy, 12
12345