Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

被引:1599
|
作者
Gyoergy, Bence [1 ]
Szabo, Tamas G. [1 ]
Pasztoi, Maria [1 ,2 ]
Pal, Zsuzsanna [1 ]
Misjak, Petra [1 ]
Aradi, Borbala [1 ]
Laszlo, Valeria [1 ]
Pallinger, Eva [1 ,2 ]
Pap, Erna [1 ]
Kittel, Agnes [3 ]
Nagy, Gyoergy [1 ,4 ]
Falus, Andras [1 ,2 ]
Buzas, Edit I. [1 ]
机构
[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary
[2] Hungarian Acad Sci, Res Grp Inflammat Biol & Immunogenom, Budapest, Hungary
[3] Hungarian Acad Sci, Inst Expt Med, Budapest, Hungary
[4] Semmelweis Univ, Dept Rheumatol, H-1089 Budapest, Hungary
关键词
Exosome; Microvesicle; Microparticle; Apoptotic body; Cancer; Platelet; Biomarker; Autoimmune disease; CIRCULATING ENDOTHELIAL MICROPARTICLES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLATELET-DERIVED MICROPARTICLES; FACTOR-POSITIVE MICROPARTICLES; V+ APOPTOTIC MICROPARTICLES; P2X(7) RECEPTOR; TISSUE-FACTOR; ELEVATED LEVELS; THROMBOCYTOPENIC PURPURA; INTERCELLULAR TRANSFER;
D O I
10.1007/s00018-011-0689-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.
引用
收藏
页码:2667 / 2688
页数:22
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