Swimming endurance capacity of mice after administration of exo-polymer produced from submerged mycelial culture of Ganoderma lucidum

The effect of exo-polymer from Ganoderma lucidum on the swimming endurance capacity of mice was investigated. The administration of the exo-polymer (100 mg/kg body weight) increased the swimming endurance capacity of mice by about 10 min and reduced the muscle and liver glycogen exhaustion by 18.5% and 67.2%, respectively. A substantial decrease in serum lactate accumulation (50.7%) was also achieved under the influence of the exo-polymer. The exo-polymer was determined to be a glycoprotein with a molecular weight of 780 kDa and found to contain 82.8% carbohydrate and 17.2% protein.