Gene expression induced by X-ray irradiation in human blood cell lines

被引：2
|
作者：
Mori, M
Benotmane, MA
Verheyde, J
Van Hummelen, P
Hooghe-Peters, EL
Desaintes, C
机构：
[1] CEN SCK, Radiobiol Lab, Studies Cent Kernenergie, Ctr Etude Energie Nucl, B-2400 Mol, Belgium
[2] Flanders Interuniv Inst Biotechnol VIB, MicroArray Facil, B-3000 Louvain, Belgium
[3] Free Univ Brussels, Sch Med, Dept Pharmacol, B-1090 Brussels, Belgium
来源：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷
关键词：
X rays; irradiation; Jurkat; Raji; HL60;
D O I：
10.1196/annals.1299.061
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The response to X-ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being the least sensitive. The profile of gene expression was studied with the microarray technique in both Jurkat and HL60 cell lines. Out of the 13,800 different genes spotted on microarrays, very few genes (<0.5%) appeared to be induced more than 2-fold or repressed more than 2.5-fold in both cell lines.
引用
收藏
页码：339 / 341
页数：3
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