Premature birth and preterm rupture of the amnion

About 30-40% of premature births are caused by the ruptures of the amnion. This is associated with a substantial increase in the risk of maternal and fetal morbidity and mortality. The biochemical processes within the amnion which are relevant to preterm rupture are becoming increasingly better understood. Ascending infections from the vagina seem to be one of the main factors leading to premature amniotic rupture. The diagnosis of both preterm ruptures as well as of potentially underlying intrauterine infections may be difficult. Early verification is, however, mandatory for further clinical management. Antenatal glucocorticoid application is one of the few extensively investigated therapies and the systemic application of antibiotics also seems to have advantages.