Decrease in NF-κB, AP-I and SP-I activities in neuronal cells expressing presenilin 2

被引：7

作者：

Nguyen, HN

Lee, SY

Hwang, DY

Kim, YK

Yuk, DY

Lee, JS

Hong, JT ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea

[2] Chungbuk Natl Univ Hosp, Cheongju 361763, Chungbuk, South Korea

[3] Korea Food & Dug Adm, Natl Inst Toxicol Res, Seoul 122704, South Korea

来源：

NEUROREPORT | 2005年 / 16卷 / 07期

关键词：

AP-I; neuronal cells; NF-kappa B; presenilin; 2; SP-I;

D O I：

10.1097/00001756-200505120-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Decreases in activities of the NF-kappa B, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study. Similar results were also found in mice brain cells carrying presenilin 2, especially in the mutant gene expressed ones. These findings suggested that presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors. NeuroReport 16:731-735 (c) 2005 Lippincott Williams & Wilkins.

引用

页码：731 / 735

页数：5

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