Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy

被引：113
|
作者：
Nombona, Nolwazi [1 ]
Maduray, Kaminee [2 ]
Antunes, Edith [1 ]
Karsten, Aletta [2 ]
Nyokong, Tebello [1 ]
机构：
[1] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa
[2] CSIR, Natl Laser Ctr, ZA-0001 Pretoria, South Africa
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2012年 / 107卷
基金：
新加坡国家研究基金会;
关键词：
Phthalocyanine; Gold nanoparticles; Liposome; Photodynamic therapy; PHOTOPHYSICAL PROPERTIES; SINGLET OXYGEN; QUANTUM YIELDS; DELIVERY; PHOTOSENSITIZERS; SUBSTITUENTS; MELANOMA; SYSTEMS; CANCER; STATE;
D O I：
10.1016/j.jphotobiol.2011.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5J cm(-2). The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement kin PDT activity. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：35 / 44
页数：10
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