An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO2 Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

被引：22
|
作者：
Khalafi-Nezhad, Ali [1 ]
Haghighi, Saghar Mowlazadeh [1 ]
Purkhosrow, Azar [2 ]
Panahi, Farhad [1 ]
机构：
[1] Shiraz Univ, Shiraz 71454, Iran
[2] Shiraz Univ Med Sci, Sch Med, Dept Pharmacol, Cardiovasc Pharmacol Res Lab, Shiraz 71454, Iran
来源：
SYNLETT | 2012年 / 06期
关键词：
quinazolinone; multicomponent reaction; TiO2; nanoparticles; heterogeneous catalyst; vasorelaxant activity; SOLVENT-FREE CONDITIONS; 4(3H)-QUINAZOLINONE DERIVATIVES; HYDROGEN-PEROXIDE; HETEROCYCLIC SYNTHESIS; MICROWAVE IRRADIATION; DEPRESSANT ACTIVITY; CASCADE SYNTHESIS; RECEPTOR; DESIGN; NUCLEOSIDE;
D O I：
10.1055/s-0031-1290610
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A variety of quinazolinone derivatives were successfully synthesized, via a three-component condensation reaction between anthranilic acid, acetic anhydride, and amines. This process was accomplished in the presence of catalytic amount of titanium dioxide nanoparticles (nano-TiO2), under solvent-free conditions. The synthesized compounds were evaluated for their vasorelaxant activity as they revealed a range of activities on the isolated thoracic rat aorta.
引用
收藏
页码：920 / 924
页数：5
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