One-Pot Four-Component Synthesis of N2-Alkyl-N3-[2-(1,3,4-oxadiazol-2-yl)aryl]benzofuran-2,3-diamines

被引：11
|
作者：
Adib, Mehdi [1 ]
Sheikhi, Ehsan [1 ]
Karimzadeh, Morteza [1 ]
Bijanzadeh, Hamid Reza [2 ]
Amanlou, Massoud [3 ,4 ]
机构：
[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran
[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
[3] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Med Chem, Tehran, Iran
来源：
HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 05期
关键词：
Benzofuran-2; 3-diamines; Multicomponent reactions; PALLADIUM-CATALYZED HETEROANNULATION; SOLID-PHASE SYNTHESIS; SUR LE BENZOFURANNE; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FURAN-DERIVATIVES; CASCADE REACTIONS; ACID-DERIVATIVES;
D O I：
10.1002/hlca.201100403
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple synthesis of N2-alkyl-N3-[2-(1,3,4-oxadiazol-2-yl)aryl]benzofuran-2,3-diamines 5 via a one-pot four-component reaction is described (Scheme 1). A mixture of N-(isocyanoimino)triphenylphosphorane (1), a 2-aminobenzoic acid 2, a 2-hydroxybenzaldehyde 3, and an isocyanide 4 in absolute EtOH at room temperature undergoes a smooth reaction to afford 5 in excellent yields (Table).
引用
收藏
页码：788 / 794
页数：7
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