This piece uses the Doce River case (2015) to illustrate the gendered impacts of the failure of corporate human rights due diligence. We also ask the question: would the Gender Dimensions of the Guiding Principles on Business and Human Rights(1) (Gender Guidance) have made a difference to the way women were treated in preventive measures taken and in the application of redress mechanisms? Taking this specific case, we seek to illustrate the importance of integrating gender into international business and human rights (BHR) frameworks if women's rights are to be protected and respected in the context of business activities.