A practical synthetic route to benzofuro[2,3-b]pyridine and trifluoromethyl-α-carbolines

被引：21

作者：

Iaroshenko, Viktor O. ^{[1
,2
]}

Groth, Ulrich ^{[1
]}

Kryvokhyzha, Nadiya V. ^{[3
]}

Obeid, Samra ^{[1
]}

Tolmachev, Andrei A. ^{[2
,4
]}

Wesch, Thomas ^{[1
]}

机构：

[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany

[2] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine

[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

[4] Enamine Ltd, UA-01103 Kiev, Ukraine

来源：

SYNLETT | 2008年 / 03期

关键词：

furanamine; indoleamine; pyridine; annulation; electrophilic aromatic substitution;

D O I：

10.1055/s-2008-1032042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In situ generated benzofuran-2-amine reacts with 1,3-CCC-diclectrophiles, such as CF3-containing beta-diketones, 3-formylchromone, methyl-2,4-dioxopentanoate and pentafluorobenzaldehyde, and the reaction leads to the formation of benzofuro[2,3-b]pyridine ring system. By using a similar approach 4-trifluoromethyl-alpha-carbolines were synthesized starting from indole-2-amine.

引用

页码：343 / 346

页数：4

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