Synthesis of Pyrrolidine- and γ-Lactam-Containing Natural Products and Related Compounds from Pyrrole Scaffolds

被引：13

作者：

Olivier, Wesley J. ^{[1
]}

Smith, Jason A. ^{[1
]}

Bissember, Alex C. ^{[1
]}

机构：

[1] Univ Tasmania Hobart, Sch Nat Sci Chem, Hobart, Tas, Australia

来源：

CHEMICAL RECORD | 2022年 / 22卷 / 03期

关键词：

pyrrole; pyrrolidine; alkaloids; natural products; total synthesis; ONE-POT SYNTHESIS; SINGLET-OXYGEN; ASYMMETRIC-SYNTHESIS; FORMAL SYNTHESIS; SIMPLE FURANS; ALKALOIDS; INDOLIZIDINE; PYRROLIZIDINE; CYCLIZATION; TRANSFORMATION;

D O I：

10.1002/tcr.202100277

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polycyclic alkaloid natural products featuring pyrrolidine and pyrrolidinone motifs remain enduring targets of total synthesis endeavors. Pyrrole and its derivatives have been exploited to access many such frameworks, including alkaloids belonging to the Aspidosperma, Stemona, and batzelladine families. In this article, a selection of exemplars that highlight the utility of pyrrole-based approaches to facilitate total syntheses of pyrrolidine- and pyrrolidinone-containing alkaloids and related molecules are showcased.

引用

页数：17

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