Excited-state pKa values of curcumin

被引：0
|
作者：
Zhao, Qian [1 ]
Kong, De-Xin [1 ]
Zhang, Hong-Yu [1 ]
机构：
[1] Shandong Univ Technol, Ctr Adv Study, Shandong Provincial Res Ctr Bioinformat Engn & Te, Zibo 255049, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2008年 / 3卷 / 02期
关键词：
curcumin; pKa values; excited state; Forster cycle;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Curcumin is one of the most extensively studied natural pigments. The significant phototoxicity of curcumin against a variety of bacteria and viruses has made the pigment a potential photodynamic drug. To explore whether the phototoxic mechanisms of curcumin involve light-induced acidification, the excited-state pKa values of the pigment were determined by the Forster cycle. It was found that the excited-state pKa values of curcumin [i.e., 7.56 (7.72), 8.72 (8.14) and 10.17 (10.35)] are rather higher than those of counterpart phenolic photosensitizers, which implies that light-induced acidification is unlikely to be responsible for the phototoxicity of curcumin.
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页码：229 / 232
页数：4
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