Diltiazem does not always increase blood cyclosporin concentration

被引：10
|
作者：
Jones, TE [1 ]
Morris, RG [1 ]
机构：
[1] QUEEN ELIZABETH HOSP, DEPT CLIN PHARMACOL, WOODVILLE, SA 5011, AUSTRALIA
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1996年 / 42卷 / 05期
关键词：
cyclosporin; diltiazem; itraconazole; interaction; pharmacokinetic;
D O I：
10.1111/j.1365-2125.1996.tb00062.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetic interaction between the calcium channel blocking drug, diltiazem (DTZ), the antifungal agent itraconazole (ICZ) and the immunosuppressive drug cyclosporin (CsA) was studied in a patient with a single lung transplant. The CsA area under curve estimations demonstrated a significant increase when ICZ was co-prescribed (5836 mu g l(-1) h vs 8159 mu g l(-1) h) but no increase when DTZ was co-prescribed with CsA (5836 mu g l(-1) h vs 5069 mu g l(-1) h). Despite widespread use as a CsA-sparing agent, DTZ does not always increase CsA concentrations.
引用
收藏
页码：642 / 644
页数：3
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