Caffeic Acid Esters and Lignans from Piper sanguineispicum

被引：40

作者：

Cabanillas, Billy Joel ^{[1
,3
]}

Le Lamer, Anne-Cecile ^{[1
]}

Castillo, Denis ^{[2
]}

Arevalo, Jorge ^{[2
]}

Rojas, Rosario ^{[2
]}

Odonne, Guillaume ^{[1
]}

Bourdy, Genevieve ^{[1
,3
]}

Moukarzel, Beatrice ^{[1
]}

Sauvain, Michel ^{[1
,3
]}

Fabre, Nicolas ^{[1
]}

机构：

[1] Univ Toulouse, UPS, UMR 152, Lab Pharmacochim Subst Nat & Pharmacophores Redox, F-31062 Toulouse 9, France

[2] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Fac Ciencias & Filosofia, Lima, Peru

[3] Mission IRD, UMR 152, Lima, Peru

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 11期

关键词：

LEISHMANICIDAL ACTIVITY; ABSOLUTE-CONFIGURATION; CHEMICAL-CONSTITUENTS; IN-VITRO; PLANTS; STEREOCHEMISTRY; CHEMOTHERAPY; AMAZONENSIS;

D O I：

10.1021/np1005357

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC50 2.0 and 1.8 mu M, respectively) with moderate cytotoxicity on murine macrophages.

引用

页码：1884 / 1890

页数：7

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