Novel method for targeting sphingosine kinase 2: Design, synthesis, and evaluation of bisubstrate inhibitors

被引:0
|
作者
Dawson, Thomas [1 ]
Dyer, Robert [1 ]
Kharel, Yugesh [2 ]
Lynch, Kevin [2 ]
Macdonald, Timothy [1 ,2 ]
机构
[1] Univ Virginia, Chem, Charlottesville, VA USA
[2] Univ Virginia, Pharmacol, Charlottesville, VA USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
143
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Design, synthesis, and evaluation of novel sphingosine kinase-1 inhibitors
    Grattan, T. Christian
    Wilson, Matthew R.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [2] Design and synthesis of sphingosine kinase 2 inhibitors
    Bolden, Morgan L.
    Kennedy, Andrew J.
    Mathews, Thomas P.
    Lynch, Kevin R.
    Macdonald, Timothy L.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [3] Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors
    Vogt, Dominik
    Weber, Julia
    Ihlefeld, Katja
    Brueggerhoff, Astrid
    Proschak, Ewgenij
    Stark, Holger
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (19) : 5354 - 5367
  • [4] Design, synthesis, and evaluation of novel modular bisubstrate analogue inhibitors of farnesyltransferase
    Schlitzer, M
    Sattler, I
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1999, 38 (13-14) : 2032 - 2034
  • [5] Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
    Tibrewal, Nidhi
    Elliott, Gregory, I
    CHEMMEDCHEM, 2020, 15 (23) : 2269 - 2272
  • [6] Non-traditional methods in targeting sphingosine kinase 2: Using bisubstrate inhibitors to improve potency and selectivity
    Dawson, Thomas
    Dyer, Robert
    Kharel, Yugesh
    Lynch, Kevin
    Macdonald, Timothy
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [7] Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity
    Childress, Elizabeth S.
    Kharel, Yugesh
    Brown, Anne M.
    Bevan, David R.
    Lynch, Kevin R.
    Santos, Webster L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (09) : 3933 - 3957
  • [8] Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors
    Wang, ShaSha
    Huo, Yidan
    Zhang, Jinmiao
    Li, Longfei
    Cao, Fei
    Song, Yali
    Zhang, Yajing
    Yang, Kan
    BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 93
  • [9] Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase
    Chen, Tao
    Liu, Yan
    Shi, Mingsong
    Tang, Minghai
    Si, Wenting
    Yuan, Xue
    Wen, Yi
    Chen, Lijuan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 54
  • [10] Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors
    Raje, Mithun R.
    Knott, Kenneth
    Kharel, Yugesh
    Bissel, Philippe
    Lynch, Kevin R.
    Santos, Webster L.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (01) : 183 - 194